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Title:
NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE
Document Type and Number:
WIPO Patent Application WO/2015/026990
Kind Code:
A8
Abstract:
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, -NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)2, -OH, C1-C6 alkoxy, and C1-C6 haloalkoxy; X is a bond, −CH2-, -CHR5-, -C=CHR4-, -NR4-, -N=O-R4-, −O-, −S-, −SO-, −SO2-, −C(O)-, or −C(NR4)-, or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each R4 is independently hydrogen or C1-6 alkyl; R5 is independently hydrogen, C1-6 alkyl, or −OR6, where R6 is selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyL C3-12 cycloalkyl, heterocyclyl, aryl, arylC1-6 alkyl, heteroaryl, or heteroarylC1-6 alkyl; Y is C1-6 alkylene, C2-6 alkenylene, or C2-6 alkylylene moiety.

Inventors:
BUTTRICK, Brian (Center for Commercialization4311 11th Avenue NE, Suite 50, Seattle WA, 98105, US)
GUILLOTEAU, Nicolas (1400 S. 5th Street W, Apartment 1Missoula, MT, 59801, US)
DIAZ, Philippe (32 Campus Drive Skaggs Building, CHPBS-BME, Missoula MT, 59812, US)
ISOHERRANEN, Nina (Center for Commercialization4311 11th Avenue NE, Suite 50, Seattle WA, 98105, US)
Application Number:
US2014/051962
Publication Date:
November 12, 2015
Filing Date:
August 20, 2014
Export Citation:
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Assignee:
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (4311 11th Avenue NE, Suite 500Seattle, WA, 98105, US)
UNIVERSITY OF MONTANA (32 Campus Drive, Skaggs Building CHPBS-BME, Missoula MT, 59812, US)
BUTTRICK, Brian (Center for Commercialization4311 11th Avenue NE, Suite 50, Seattle WA, 98105, US)
GUILLOTEAU, Nicolas (1400 S. 5th Street W, Apartment 1Missoula, MT, 59801, US)
International Classes:
C07D317/30; A61K31/216; A61K31/357; A61K31/385; C07C57/50; C07C59/54; C07C59/72; C07C59/86; C07C69/616; C07C69/73; C07C69/734; C07C229/42; C07C229/44; C07C317/44; C07C317/46; C07C323/62; C07D339/06
Attorney, Agent or Firm:
LIBBY, Jelena Janjic (McDonnell Boehnen Hulbert & Berghoff LLP, 300 South Wacker Drive Suite 310, Chicago IL, 60606, US)
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