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Title:
NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE
Document Type and Number:
WIPO Patent Application WO/2015/026990
Kind Code:
A8
Abstract:
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, -NH2, -NH(C1-C6 alkyl), -N(C1-C6 alkyl)2, -OH, C1-C6 alkoxy, and C1-C6 haloalkoxy; X is a bond, −CH2-, -CHR5-, -C=CHR4-, -NR4-, -N=O-R4-, −O-, −S-, −SO-, −SO2-, −C(O)-, or −C(NR4)-, or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each R4 is independently hydrogen or C1-6 alkyl; R5 is independently hydrogen, C1-6 alkyl, or −OR6, where R6 is selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyL C3-12 cycloalkyl, heterocyclyl, aryl, arylC1-6 alkyl, heteroaryl, or heteroarylC1-6 alkyl; Y is C1-6 alkylene, C2-6 alkenylene, or C2-6 alkylylene moiety.

Inventors:
BUTTRICK BRIAN (US)
GUILLOTEAU NICOLAS (US)
DIAZ PHILIPPE (US)
ISOHERRANEN NINA (US)
Application Number:
US2014/051962
Publication Date:
November 12, 2015
Filing Date:
August 20, 2014
Export Citation:
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Assignee:
UNIV WASHINGTON CT COMMERCIALI (US)
UNIV MONTANA (US)
BUTTRICK BRIAN (US)
GUILLOTEAU NICOLAS (US)
International Classes:
C07D317/30; A61K31/216; A61K31/357; A61K31/385; C07C57/50; C07C59/54; C07C59/72; C07C59/86; C07C69/616; C07C69/73; C07C69/734; C07C229/42; C07C229/44; C07C317/44; C07C317/46; C07C323/62; C07D339/06
Attorney, Agent or Firm:
LIBBY, Jelena Janjic (300 South Wacker Drive Suite 310, Chicago IL, US)
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