NOVEL SPECIFIC MONOCLONAL ANTIBODY TO ACETYLATED MOUSE BUBR1 AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2017/126944

A1

The present invention provides a rabbit monoclonal antibody to acetylated mouse BubR1 and a preparation method therefor and, more particularly, provides the use of the monoclonal antibody in a method for measuring the activity of cell division checkpoints on the basis of a degree of acetylation of BubR1, a method for detecting a tumor disease on the basis of aberrant cell division, a method for diagnosing cancer, a method for screening anti-cancer agents, or a method for regulating a cell division cycle.

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LEE HYUNSOOK (KR)
KIM HYEON-JONG (KR)
KWON MI-SUN (KR)
PARK INAI (KR)

PCT/KR2017/000746

July 27, 2017

January 20, 2017

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SNU R&DB FOUNDATION (KR)

C07K16/28; G01N33/68

KR20110019495A	2011-02-28
US20080102477A1	2008-05-01

LEE: "How Chromosome Mis-segregation Leads to Cancer: Lessons from BubR1 Mouse Models", MOLECULES AND CELLS, vol. 37, no. 10, 26 September 2014 (2014-09-26), pages 713 - 718, XP055400685
PARK ET AL.: "Loss of BubR1 Acetylation Causes Defects in Spindle Assembly Checkpoint Signaling and Promotes Tumor Formation", THE JOURNAL OF CELL BIOLOGY, vol. 202, no. 2, 22 July 2013 (2013-07-22), pages 295 - 309, XP055400687
CHOI ET AL.: "BubR1 Acetylation at Prometaphase is Required for Modulating APC/C Activity and Timing of Mitosis", THE EMBO JOURNAL, vol. 28, no. 14, 2009, pages 2077 - 2089, XP055400691

LEE, Woojin et al. (KR)

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