Title:
NOVEL SPIROQUINONE DERIVATIVE COMPOUND, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEUROLOGICAL DISORDERS WHICH CONTAINS SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/048261
Kind Code:
A1
Abstract:
The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient, and it has been confirmed that the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof may excellently suppress 'microglial activation' and shows excellent inhibition activity against acetylcholinesterase, JNK1, JNK2 and JNK3, and in addition to this, significant enzyme inhibition activity has been confirmed in a neurological diseases-related enzyme group, RIPK5, CDK3/cyclin E, PKN2/PRK2, Haspin, STK25/YSK1, ARK5/NUAK1, PKCb2, CDK2/cyclin O, DAPK1, PKCa, CDK1/cyclin B, MST3/STK24 and TLK1 and it has been confirmed that cell death suppression effect may be exhibited, and thus the novel spiroquinone derivative compound according to the present invention, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof can be usefully used for a pharmaceutical composition for preventing or treating neurological disorders or health functional food composition for preventing or improving neurological disorders by being contained therein as an active ingredient.
Inventors:
KIM MI-HYUN (KR)
KIM SUN YEOU (KR)
ARRAMSHETTI VENKANNA (KR)
KIM KANG (KR)
CHO KYOHEE (KR)
LAMA PREMA DHORMA (KR)
LEE SANG-YOON (KR)
KIM SUN YEOU (KR)
ARRAMSHETTI VENKANNA (KR)
KIM KANG (KR)
CHO KYOHEE (KR)
LAMA PREMA DHORMA (KR)
LEE SANG-YOON (KR)
Application Number:
PCT/KR2017/009909
Publication Date:
March 15, 2018
Filing Date:
September 08, 2017
Export Citation:
Assignee:
UNIV GACHON IND ACAD COOP FOUND (KR)
GIL MEDICAL CT (KR)
GIL MEDICAL CT (KR)
International Classes:
C07D265/14; A23L33/10; A61K31/537
Foreign References:
| JPH10268489A | 1998-10-09 | |||
| CN102850337A | 2013-01-02 | |||
| CN105085433A | 2015-11-25 | |||
| US20100056613A1 | 2010-03-04 | |||
| KR20020040160A | 2002-05-30 |
Other References:
See also references of EP 3395804A4
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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