Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL STABLE CRYSTAL OF 1-(2'-CYANO-2'-DEOXY-β-D-ARABINOFURANOSYL)CYTOSINE MONOHYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2010/131475
Kind Code:
A1
Abstract:
Disclosed is a stable crystal of 1-(2'-cyano-2'-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride. The crystal of 1-(2'-cyano-2'-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride shows characteristic peaks at 13.7°, 15.7°, 16.0°, 18.6°, 20.3°, and 22.7° as diffraction angles (2θ ± 0.1°) by powder X-ray diffractometry and has a melting point of 192 to 197°C.

Inventors:
WATANABE SHOTARO (JP)
HATAKEYAMA TAKAHIRO (JP)
Application Number:
PCT/JP2010/003261
Publication Date:
November 18, 2010
Filing Date:
May 14, 2010
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
MATSUDA AKIRA (JP)
SASAKI TAKUMA (JP)
WATANABE SHOTARO (JP)
HATAKEYAMA TAKAHIRO (JP)
International Classes:
C07H19/06; A61K31/7068; A61P35/00
Foreign References:
JPH04235182A1992-08-24
JP2559917B21996-12-04
JPH04235182A1992-08-24
Other References:
AZUMA, A ET AL.: "Nucleosides and Nucleotides. 141.Chemical Stability of a New Antitumor Nucleoside, 2'-C-Cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC) in Alkaline Medium: Formation of 2'-C-Cyano-2'-deoxy-1-beta-D-ribo-pentofuranosylcytosine (CNDC) and Its Antitumor Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 17, 1995, pages 3391 - 3397, XP055103106
AZUMA, A. ET AL.: "Nucleosides and nucleotides. 122. 2'-C-Cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 26, 1993, pages 4183 - 4189, XP002997578
NORIAKI HIRAYAMA, ET AL.: "Kessho Sakusei Handbook -Genri to KnowHow", 25 July 2008, article NORIAKI HIRAYAMA ET AL., pages: 57-62 - 78-81
MATSUDA, A. ET AL.: "Synthesis of a new potent antitumor nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 22, 1990, pages 51 - 52, XP008111983
JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, 1991, pages 2917 - 2919
JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, 1993, pages 4183 - 4189
INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 60, 1990, pages 11 - 26
ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 4, 2000, pages 413 - 417
BUNRI GIJUTSU, SEPARATION TECHNOLOGY, vol. 33, 2003, pages 379 - 385
ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 9, 2005, pages 933 - 942
See also references of EP 2431376A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Download PDF:
Claims: