Title:
NOVEL STATIN INTERMEDIATE, AND PRODUCTION METHOD FOR PITAVASTATIN, ROSUVASTATIN, CERIVASTATIN AND FLUVASTATIN USING SAME
Document Type and Number:
WIPO Patent Application WO/2013/172687
Kind Code:
A1
Abstract:
The present invention provides a novel statin intermediate represented by chemical formula 1, and a method for producing pitavastatin, rosuvastatin, cerivastatin and fluvastatin by using the intermediate. (In chemical formula 1: n = 1, 2 or 3; Ar = a phenyl group or a phenyl group substituted with a C1-C4 alkyl or C6-C10 aryl, a naphthyl group or a naphthyl group substituted with a C1-C4 alkyl or C6-C10 aryl, or an anthracene group or an anthracene group substituted with a C1-C4 alkyl or C6-C10 aryl; and R1 is a C1-C8 alkyl, secondary alkyl, tertiary alkyl, aryl or aralkyl.)
Inventors:
GOO YOUNG-SAM (KR)
KIM JEONG-TAE (KR)
KIM JEONG-TAE (KR)
Application Number:
PCT/KR2013/004380
Publication Date:
November 21, 2013
Filing Date:
May 16, 2013
Export Citation:
Assignee:
FNG RES CO LTD (KR)
International Classes:
C07C15/28; C07C15/24; C07F3/04; C07F5/02
Foreign References:
| KR100598079B1 | 2006-07-07 | |||
| KR20110114888A | 2011-10-20 | |||
| US4970313A | 1990-11-13 |
Other References:
PINTARIC, CHRISTINE ET AL.: "An Opportunity for Mg-Catalyzed Grignard-Type Reactions: Direct Coupling of Benzylic Halides with Pinacolborane with 10 mol % of Magnesium.", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 11825 - 11827
Attorney, Agent or Firm:
SA, Kwang-young (KR)
사광영 (KR)
사광영 (KR)
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