NOVEL STEM CELL TRANSPORTER AND METHOD FOR PRODUCING SAME

Title:

NOVEL STEM CELL TRANSPORTER AND METHOD FOR PRODUCING SAME

Document Type and Number:

WIPO Patent Application WO/2018/044124

Kind Code:

A1

Abstract:

The present invention relates to a novel stem cell transporter and a method for producing the same, and provides a method for producing a stem cell transporter comprising a step of contacting a stem cell with a coacervate formed by mixing an anionic polymer with a mussel adhesive protein or a variant thereof. The present invention relates to a new stem cell therapeutic agent platform of delivering cells in a captured state by forming an adhesive cell transporter using crosslinked coacervate. The cell transporter of the present invention can maintain the ability to differentiate stem cells as well as biocompatibility and can survive without losing cell adhesion even under oxygen-deficient conditions. In addition, the cell transporter of the present invention has an excellent regenerative effect by applying such to biological tissues in which vascular regeneration is not easy, by inducing a metabolic reaction triggered by hypoxic environment, in particular, neovascularization.

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Inventors:

CHA HYUNG JOON (KR)
PARK TAE YOON (KR)
KIM HYO JEONG (KR)
CHOI BONG HYUK (KR)

Application Number:

PCT/KR2017/009614

Publication Date:

March 08, 2018

Filing Date:

September 01, 2017

Export Citation:

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Assignee:

POSTECH ACAD IND FOUND (KR)

International Classes:

A61K9/51; A61K9/10; A61K9/127; A61K47/30; A61L27/14; A61L27/36; A61L27/40

Domestic Patent References:

WO2009029406A1

2009-03-05

Foreign References:

KR20120013626A	2012-02-15
US20060019362A1	2006-01-26
US20100120923A1	2010-05-13

Other References:

WEN, Z. ET AL.: "Repair Me chanisms of Bone Marrow Mesenchymal Stem Cells in Myocardial Infarction", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 15, no. 5, 26 May 2011 (2011-05-26), pages 1032 - 1043, XP055471744, Retrieved from the Internet

Attorney, Agent or Firm:

KIM, Soon Woong (KR)

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