Title:
NOVEL STEROID GLYCOSIDE, NGF-ASSOCIATED ACTIVE SUBSTANCE, PROCESS FOR PRODUCING THE SAME, METHOD OF SCREENING THEREOF, AND CEREBRAL DYSFUNCTION PREVENTIVE AGENT
Document Type and Number:
WIPO Patent Application WO/2006/090910
Kind Code:
A1
Abstract:
A novel steroid glycoside having an NGF-associated activity, represented by the general formula: (1) This steroid glycoside has an NGF-associated activity.
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Inventors:
OJIKA MAKOTO (JP)
QI JIANHUA (JP)
SAKAGAMI YOUJI (JP)
MAMIYA TAKAYOSHI (JP)
QI JIANHUA (JP)
SAKAGAMI YOUJI (JP)
MAMIYA TAKAYOSHI (JP)
Application Number:
PCT/JP2006/304036
Publication Date:
August 31, 2006
Filing Date:
February 24, 2006
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
OJIKA MAKOTO (JP)
QI JIANHUA (JP)
SAKAGAMI YOUJI (JP)
MAMIYA TAKAYOSHI (JP)
OJIKA MAKOTO (JP)
QI JIANHUA (JP)
SAKAGAMI YOUJI (JP)
MAMIYA TAKAYOSHI (JP)
International Classes:
C07J9/00; A61K31/704; A61K35/56; A61K35/616; A61K45/00; A61P25/00; A61P25/28; A61P43/00; B01J20/283; B01J20/285; G01N30/88; G01N30/94
Other References:
QI J. ET AL.: "Linckosides C-E, three new neuritogenic steroid glycosides from the Okinawan starfish Linckia Laevigata", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 15, 2004, pages 4259 - 4265, XP003002237
QI J. ET AL.: "Linckosides A and B, two new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 6, 2002, pages 1961 - 1966, XP003002238
PIZZA C. ET AL.: "Starfish saponins. Part 20. Two novel steroidal glycosides from the starfish Acanthaster planci(L)", JOURNAL OF CHEMICAL RESEARCH(S) & JOURNAL OF CHEMICAL RESEARCH(M), vol. 3, 1985, pages 76 - 77, AND 0969 - 0986, XP003002239
IORIZZI M. ET AL.: "Starfish saponins, part 53. A reinvestigation of the polar steroids from the starfish Oreaster reticulatus: isolation of sixteen steroidal oligoglycosides and six polyhydroxysteroids", JOURNAL OF NATURAL PRODUCTS, vol. 58, no. 1, 1995, pages 10 - 26, XP003002240
OJIKA H. ET AL.: "Starfish Saponin no Aratana Tenkai", DAI 8 KAI JAPANESE SOCIETY FOR MARINE BIOTECHNOLOGY TAIKAI KOEN YOSHISHU, 28 May 2005 (2005-05-28), pages 50, XP003002241
QI J. ET AL.: "Linckosides A and B, two new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 6, 2002, pages 1961 - 1966, XP003002238
PIZZA C. ET AL.: "Starfish saponins. Part 20. Two novel steroidal glycosides from the starfish Acanthaster planci(L)", JOURNAL OF CHEMICAL RESEARCH(S) & JOURNAL OF CHEMICAL RESEARCH(M), vol. 3, 1985, pages 76 - 77, AND 0969 - 0986, XP003002239
IORIZZI M. ET AL.: "Starfish saponins, part 53. A reinvestigation of the polar steroids from the starfish Oreaster reticulatus: isolation of sixteen steroidal oligoglycosides and six polyhydroxysteroids", JOURNAL OF NATURAL PRODUCTS, vol. 58, no. 1, 1995, pages 10 - 26, XP003002240
OJIKA H. ET AL.: "Starfish Saponin no Aratana Tenkai", DAI 8 KAI JAPANESE SOCIETY FOR MARINE BIOTECHNOLOGY TAIKAI KOEN YOSHISHU, 28 May 2005 (2005-05-28), pages 50, XP003002241
Attorney, Agent or Firm:
Ohkawa, Hiroshi (Nakamura-ku Nagoya-shi, Aichi 02, JP)
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