NOVEL SUBSTANCE HAVING ANTITUMOR/ANTI-INFLAMMATORY ACTIVITY

WIPO Patent Application WO/2003/051804

A1

A compound represented by the following formula (1) or a salt thereof, which have excellent antitumor activity and excellent angiogenesis inhibitory activity under low-oxygen conditions; and a medicine, such as an antitumor agent or anti-inflammatory agent, which contains as an active ingredient the compound or a physiologically acceptable salt of the compound.

JP3429310	[Title of Invention] Promotion of Indole Biosynthesis
WO/2016/084886	METHOD FOR MANUFACTURING GERMINATION-TREATED PLANT SEED, METHOD FOR MANUFACTURING RAW SEED FOR GERMINATION INDUCTION, GERMINATION TREATED PLANT SEED EXTRACT COMPOSITION, AND SCREENING METHOD
WO/2008/064837	NOVEL GENES FOR THE FERMENTATIVE PRODUCTION OF HYDROXYTYROSOL

OSADA HIROYUKI (JP)
KAKEYA HIDEAKI (JP)
KONNO HIROSHI (JP)
KANAZAWA SUSUMU (JP)

PCT/JP2002/013124

June 26, 2003

December 16, 2002

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RIKEN (JP)
INST OF BIOTECHNOLOGY APPLIED (JP)
OSADA HIROYUKI (JP)
KAKEYA HIDEAKI (JP)
KONNO HIROSHI (JP)
KANAZAWA SUSUMU (JP)

C12P7/22; A61K31/05; A61K31/222; A61L15/40; A61P29/00; A61P35/00; A61P43/00; C07C39/19; C07C69/017; C07C69/16; C12P7/62; (IPC1-7): C07C39/19; C07C69/16; C12P7/22; A61K31/05; A61K31/222; A61P29/00; A61P35/00; A61P43/00

HAMADA Y. ET AL.: "Efficient total synthesis of AI-77-B, a gastroprotective substance from bacillus pumilus AI-77", TETRAHEDRON, vol. 47, no. 40, 1991, pages 8635 - 8652, XP002965207
MALI R.S. ET AL.: "Novel AlCl3 catalyzed syntheses of naturally occurring (+/-) 8-hydroxy-3-methyl-3,4-dihydroisocoumarins", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 12, 1992, pages 883 - 884, XP002965208

SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)

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