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Title:
NOVEL SUGAR CHAIN COMPOUND CONTAINING SIALYLLACTOSAMINE-TYPE OR SIALYL LEWIS X-TYPE SIALIC ACID AND FUCOSE
Document Type and Number:
WIPO Patent Application WO/2011/046057
Kind Code:
A1
Abstract:
Provided is a novel and non-natural sialic acid-containing sugar chain compound, which has a binding activity to a viral particle and remains stable even in the presence of sialidase, obtained by using a reaction with the use of a glycosyltransferase having high substrate specificity and high reaction selectivity. A compound having a sugar chain structure represented by general formula (1): Siaα2-3(Siaα2-6)Galβ1-4(Fucα1-3)GlcNAc (1), or a salt thereof.

Inventors:
SHIMIZU Hiroki (National Institute of Advanced Industrial Science and Technology 2-1, Tsukisamu-higashi 2-jo 17-chome, Toyohira-ku, Sapporo-sh, Hokkaido 17, 〒0628517, JP)
清水 弘樹 (〒17 北海道札幌市豊平区月寒東2条17丁目2番1号 独立行政法人産業技術総合研究所 北海道センター内 Hokkaido, 〒0628517, JP)
Application Number:
JP2010/067614
Publication Date:
April 21, 2011
Filing Date:
October 07, 2010
Export Citation:
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Assignee:
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (3-1 Kasumigaseki 1-chome, Chiyoda-ku Tokyo, 21, 〒1008921, JP)
独立行政法人産業技術総合研究所 (〒21 東京都千代田区霞が関一丁目3番1号 Tokyo, 〒1008921, JP)
SHIMIZU Hiroki (National Institute of Advanced Industrial Science and Technology 2-1, Tsukisamu-higashi 2-jo 17-chome, Toyohira-ku, Sapporo-sh, Hokkaido 17, 〒0628517, JP)
International Classes:
C07H15/04; A61K31/702; A61K31/7028; A61P31/12; A61P31/16; A61P43/00; C07H7/027
Foreign References:
JP2007308444A2007-11-29
JPH10500948A1998-01-27
JP2007527539A2007-09-27
JP2006223198A2006-08-31
JP2006271372A2006-10-12
JP2007297521A2007-11-15
JP2008195667A2008-08-28
Other References:
YASUHIRO KAJIHARA, ET AL.: "A Novel alpha-2,6-Sialyltransferase: Transfer of Sialic Acid to Fucosyl and Sialyl Trisaccharides", JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, pages 8632 - 8635, XP055072421, DOI: doi:10.1021/jo961214v
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (Kamiya-cho MT Bldg. 19F, 3-20 Toranomon 4-chome, Minato-k, Tokyo 01, 〒1050001, JP)
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