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Title:
NOVEL SUGAR DERIVATIVES AS SGLT2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2011/070592
Kind Code:
A3
Abstract:
The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2). The invention also relates to the use of compounds of Formula I, their pharmaceutically acceptable derivatives, analogs, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof, for the manufacture of a medicament for the prophylaxis, amelioration and/or treatment of conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2) and the related diseases, disorders and conditions, in a subject in need thereof.

Inventors:
JAIN, Rajesh (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
TREHAN, Sanjay (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
THUNGATHURTHI, Sastry V.R.S. (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
NANDA, Gurmeet, Kaur (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
DAS, Jagattaran (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
MAGADI, Sitaram, Kumar (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
SHARMA, Sudhir, Kumar (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
Application Number:
IN2010/000796
Publication Date:
May 10, 2012
Filing Date:
December 09, 2010
Export Citation:
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Assignee:
PANACEA BIOTEC LTD. (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
JAIN, Rajesh (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
TREHAN, Sanjay (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
THUNGATHURTHI, Sastry V.R.S. (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
NANDA, Gurmeet, Kaur (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
DAS, Jagattaran (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
MAGADI, Sitaram, Kumar (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
SHARMA, Sudhir, Kumar (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
International Classes:
C07H15/203; C07D309/10
Domestic Patent References:
WO2009026537A12009-02-26
WO2001027128A12001-04-19
Attorney, Agent or Firm:
GUPTA, Bhartee (B-1 Extn./A-27, Mohan Co.op. Indl. EstateMathura Road, New Delhi 4, 110 04, IN)
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