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Title:
NOVEL SYNTHETIC GLYCOLIPID AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/096536
Kind Code:
A1
Abstract:
Disclosed is a compound represented by general formula (1) or a salt thereof, which is capable of preferentially inducing the production of IFN-γ in NKT cells and is therefore useful for the prevention or treatment of cancer or infectious diseases. (In the formula, R1 represents an aldopyranose residue wherein a hydroxy group at the 6-position may be alkylated; R2 represents an optionally substituted hydrocarbon group having 1-26 carbon atoms; R3 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-26 carbon atoms; R4 represents an optionally substituted hydrocarbon group having 1-21 carbon atoms; X represents an oxygen atom or a -CH2- group; and Y represents a -CH2- group, a -CH(OH)- group or a -CH=CH- group.)

Inventors:
TASHIRO, Takuya (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 〒2300045, JP)
田代 卓哉 (〒45 神奈川県横浜市鶴見区末広町1丁目7番22号 独立行政法人理化学研究所 横浜研究所内 Kanagawa, 〒2300045, JP)
MORI, Kenji (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 〒2300045, JP)
森 謙治 (〒45 神奈川県横浜市鶴見区末広町1丁目7番22号 独立行政法人理化学研究所 横浜研究所内 Kanagawa, 〒2300045, JP)
SHIOZAKI, Masao (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 〒2300045, JP)
Application Number:
JP2011/052415
Publication Date:
August 11, 2011
Filing Date:
February 04, 2011
Export Citation:
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Assignee:
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 〒3510198, JP)
独立行政法人理化学研究所 (〒98 埼玉県和光市広沢2番1号 Saitama, 〒3510198, JP)
TASHIRO, Takuya (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 〒2300045, JP)
田代 卓哉 (〒45 神奈川県横浜市鶴見区末広町1丁目7番22号 独立行政法人理化学研究所 横浜研究所内 Kanagawa, 〒2300045, JP)
MORI, Kenji (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 〒2300045, JP)
森 謙治 (〒45 神奈川県横浜市鶴見区末広町1丁目7番22号 独立行政法人理化学研究所 横浜研究所内 Kanagawa, 〒2300045, JP)
International Classes:
C07H15/04; A61K31/7032; A61P31/00; A61P35/00; A61P37/04
Domestic Patent References:
WO2009119692A1
WO2007049819A1
WO1998044928A1
WO2003105769A2
WO2007099999A1
WO2008082156A1
Foreign References:
JP2004131481A
JP2005263797A
JPH0193562A
JP2010024859A
Other References:
See also references of EP 2532671A1
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Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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Claims: