Title:
NOVEL TACROLIMUS DERIVATIVES, A NEUROPROTECTIVE COMPOSITION COMPRISING THE SAME, AN IMMUNOSUPPRESSIVE COMPOSITION COMPRISING THE SAME, A METHOD FOR PREPARING THE SAME, AND A MUTANT FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2012/026665
Kind Code:
A1
Abstract:
The present invention relates to novel tacrolimus derivatives, a neuroprotective composition comprising the derivatives, an immunosuppressive composition comprising the derivatives, a method for producing the derivatives using a specific gene-deletion mutant, and a mutant for producing the derivatives. The novel tacrolimus derivatives, which are more excellent in neuroprotective and immunosuppressive effects than tacrolimus, can be efficiently produced by using the method of the present invention.
Inventors:
YOON YEO JOON (KR)
KIM JAE JONG (KR)
LIM SI KYU (KR)
KIM JAE JONG (KR)
LIM SI KYU (KR)
Application Number:
PCT/KR2011/003644
Publication Date:
March 01, 2012
Filing Date:
May 17, 2011
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
YOON YEO JOON (KR)
KIM JAE JONG (KR)
LIM SI KYU (KR)
YOON YEO JOON (KR)
KIM JAE JONG (KR)
LIM SI KYU (KR)
International Classes:
C12P17/18; A61K31/395; A61P25/00; C12N1/20; C12R1/465
Foreign References:
| US20070142424A1 | 2007-06-21 | |||
| US20070191415A1 | 2007-08-16 | |||
| US20080286842A1 | 2008-11-20 | |||
| US20080160586A1 | 2008-07-03 |
Other References:
SHAFIEE, A. ET AL.: "CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TWO FK506 ANALOGS PRODUCED BY TARGETED GENE DISRUPTION IN STREPTOMYCES SP. MA6548", THE JOURNAL OF ANTIBIOTICS, vol. 50, no. 5, 1997, pages 418 - 423, XP000906741
MURAMATSU, H. ET AL., ACTINOMYCETOLOGICA, vol. 19, 2005, pages 33 - 39
KIM, H. S. ET AL.: "Isolation and identification of a novel microorganism producing the immunosuppressant tacrolimus", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 105, no. 4, April 2008 (2008-04-01), pages 418 - 421, XP022672660
BOX, S. J. ET AL.: "27-O-DEMETHYLRAPAMYCIN, AN IMMUNOSUPPRESSANT COMPOUND PRODUCED BY A NEW STRAIN OF STREPTOMYCES HYGROSCOPICUS", THE JOURNAL OF ANTIBIOTICS, vol. 48, no. 11, 1995, pages 1347 - 1349, XP000995832
MURAMATSU, H. ET AL., ACTINOMYCETOLOGICA, vol. 19, 2005, pages 33 - 39
KIM, H. S. ET AL.: "Isolation and identification of a novel microorganism producing the immunosuppressant tacrolimus", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 105, no. 4, April 2008 (2008-04-01), pages 418 - 421, XP022672660
BOX, S. J. ET AL.: "27-O-DEMETHYLRAPAMYCIN, AN IMMUNOSUPPRESSANT COMPOUND PRODUCED BY A NEW STRAIN OF STREPTOMYCES HYGROSCOPICUS", THE JOURNAL OF ANTIBIOTICS, vol. 48, no. 11, 1995, pages 1347 - 1349, XP000995832
Attorney, Agent or Firm:
SON, Min (6th Floor, City Air Tower, 159-9 Samseong-dong, Gangnam-gu, Seoul 135-973, KR)
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