Title:
NOVEL TENOFOVIR ALAFENAMIDE SALT AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/222393
Kind Code:
A1
Abstract:
The present inventors have researched and made efforts to overcome the problems of currently commercially available tenofovir alafenamide hemifumarate, such as low water solubility and an oral absorption rate of only 1%, and to develop a novel salt form capable of enhancing a pharmacological effect. As a result, tenofovir alafenamide heminapadisylate having water solubility 240 times that of tenofovir alafenamide hemifumarate can be used as a therapeutic or preventive pharmaceutical composition that is useful for the treatment of HIV-1 infection and chronic hepatitis B.
Inventors:
AN JI HUN (KR)
KO MIN JU (KR)
KO MIN JU (KR)
Application Number:
PCT/KR2019/018435
Publication Date:
November 05, 2020
Filing Date:
December 24, 2019
Export Citation:
Assignee:
UNICEL LAB CO LTD (KR)
International Classes:
C07F9/6561; A61K31/675; A61P31/18; A61P31/20; C07C309/35
Foreign References:
| CN105085571A | 2015-11-25 | |||
| KR20140054068A | 2014-05-08 | |||
| US20180179208A1 | 2018-06-28 | |||
| US20180265530A1 | 2018-09-20 | |||
| KR102054104B1 | 2019-12-09 |
Attorney, Agent or Firm:
JHO, Hyun Joong (KR)
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