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Document Type and Number:
WIPO Patent Application WO/2018/199166
Kind Code:
The purpose of the present invention is to provide: compounds having a TrkA inhibiting effect, or pharmacologically acceptable salts thereof, or solvates of these; pharmaceutical compositions characterized by containing these as an active ingredient; and the pharmaceutical application of these, especially agents for the prevention and/or treatment of diseases involving TrkA (such as pain, cancer, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infections, Sjogren's syndrome, endometriosis, kidney diseases, and osteoporosis). Specifically, provided are compounds represented by formula (I) or optical isomers thereof, or pharmacologically acceptable salts of these, or solvates of these, etc.

SAITOH Fumihiko (7, Yotsuya 1-chome, Shinjuku-k, Tokyo 15, 〒1608515, JP)
NAGASUE Hiroshi (7, Yotsuya 1-chome, Shinjuku-k, Tokyo 15, 〒1608515, JP)
KAWADA Yuji (7, Yotsuya 1-chome, Shinjuku-k, Tokyo 15, 〒1608515, JP)
SATOH Tsutomu (7, Yotsuya 1-chome, Shinjuku-k, Tokyo 15, 〒1608515, JP)
Application Number:
Publication Date:
November 01, 2018
Filing Date:
April 25, 2018
Export Citation:
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MOCHIDA PHARMACEUTICAL CO., LTD. (7 Yotsuya 1-chome, Shinjuku-ku Tokyo, 15, 〒1608515, JP)
International Classes:
C07D213/75; A61K31/4418; A61K31/4433; A61K31/4439; A61K31/444; A61K31/506; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P7/00; A61P9/00; A61P9/06; A61P9/12; A61P11/00; A61P11/02; A61P11/04; A61P11/06; A61P13/02; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/02; A61P19/10; A61P21/00; A61P21/02; A61P25/00; A61P25/04; A61P25/08; A61P25/16; A61P25/20; A61P25/24; A61P25/28; A61P29/00; A61P29/02; A61P31/00; A61P31/18; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P43/00; C07C213/10; C07C215/44; C07D213/38; C07D213/53; C07D213/57; C07D213/81; C07D401/04; C07D405/04; C07D405/14; C07D413/12; C07D417/04
Domestic Patent References:
Foreign References:
Other References:
DATABASE DATABASE REGISTRY [o] American Chemical Society; 28 November 2013 (2013-11-28), retrieved from STN Database accession no. 1482781-17-8
KINBARA ET AL.: "Probability of spontaneously resolvable conglomerates for racemic acid/racemic amine salts predicted on the basis of the results of diastereomeric resolutions", TETRAHEDERON: ASYMMETRY, vol. 12, no. 21, 2001, pages 2927 - 2930, XP004331580
HIGASHIJIMA ET AL.: "cis-1-Amino-1,2,3,4-tetrahydro-2-naphthalenol: resolution and application to the catalytic enantioselective reduction of ketones", TETRAHEDERON: ASYMMETRY, vol. 8, no. 18, 1997, pages 3107 - 3110, XP004090520, ISSN: 0957-4166
GUCHHAIT ET AL.: "A reaction of 1,2-diamines and aldehydes with silyl cyanide as cyanide pronucleophile to access 2-aminopyrazines and 2-aminoquinoxalines", RSC ADVANCES, vol. 6, no. 61, 6 June 2016 (2016-06-06), pages 56056 - 56063, XP055533868
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (NAKAMURA & PARTNERS, Shin-Tokyo Bldg. 3-1, Marunouchi 3-chome, Chiyoda-k, Tokyo 55, 〒1008355, JP)
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