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Patent Searching and Data


Title:
NOVEL THERAPEAUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
Document Type and Number:
WIPO Patent Application WO2005000233
Kind Code:
A3
Abstract:
The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

Inventors:
HONG BORCHERNG
SARSHAR SEPEHR (US)
TSE BRUNO (US)
Application Number:
US2004018056W
Publication Date:
August 11, 2005
Filing Date:
June 03, 2004
Export Citation:
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Assignee:
AUSPEX PHARMACEUTICALS (US)
HONG BORCHERNG
SARSHAR SEPEHR (US)
TSE BRUNO (US)
International Classes:
A61K31/12; A61K31/35; C07C49/115; C07C49/23; C07C49/747; C07C49/76; C07C49/835; C07C251/48; C07C251/86; C07D213/50; C07D213/53; C07D303/32; C07D311/78; C07D317/26; C07D319/06; C07D335/04; C07D405/04; A61K; (IPC1-7): C07C49/115; A61K31/12; A61K31/35; C07C49/23; C07C49/76; C07D311/78; C07D335/04
Foreign References:
US6844466B22005-01-18
US6825233B22004-11-30
Other References:
D. ZACHEIS ET AL.: "Heteroartinoids Inhbit Head an Neck Cancer Cell Lines in Vitro and in Vivo Througd Both RAR and RXR Retinoic Acid Receptors.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 42, 1999, pages 4434 - 4445, XP002278654
D.D.MUCCIO: "Conformationally Defined 6-s-trans-Retonic Acid Analogs. 3. Structure-Activity Relationships for Nuclear Receptor Binding, Transcriptional Activity, and Cancer Chemopreventie Activity.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, pages 3625 - 3635, XP002921457
R.L. BEARD ET AL.: "Synthesis and Structure-Activity Relatienships of Stilbene Retinoid Analogs Substituted with Heteroaromatic Carboxylic", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, 1995, pages 2820 - 2829, XP002000217
See also references of EP 1636160A4
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