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Title:
NOVEL THERAPEUTIC AGENT FOR DIABETES
Document Type and Number:
WIPO Patent Application WO/2018/043399
Kind Code:
A1
Abstract:
[Problem] To provide a novel therapeutic agent for diabetes which can be less apt to produce side effects such as persistent hypoglycemia. [Solution] A compound characterized by containing a derivative of 1,1-diphenylsemicarbazide or 1,1-diphenylthiosemicarbazide as the active ingredient. Specifically, the compound is characterized by containing a derivative of either 1,1-diphenyl-4-cyclohexylsemicarbazide or 1,1-diphenyl-4-cyclohexylthiosemicarbazide as the active ingredient, and exhibits a hypoglycemic effect when orally administered.

Inventors:
SEINO, Susumu (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 13, 〒6570013, JP)
SUGAWARA, Kenji (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 13, 〒6570013, JP)
MORI, Ichiro (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 13, 〒6570013, JP)
MATSUMOTO, Akio (1-8-1 Inohana, Chuo-ku, Chiba-sh, Chiba 56, 〒2600856, JP)
REIEN, Yoshie (1-8-1 Inohana, Chuo-ku, Chiba-sh, Chiba 56, 〒2600856, JP)
Application Number:
JP2017/030738
Publication Date:
March 08, 2018
Filing Date:
August 28, 2017
Export Citation:
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Assignee:
JCR PHARMACEUTICALS CO., LTD. (3-19, Kasuga-cho Ashiya-sh, Hyogo 21, 〒6590021, JP)
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (1-1 Rokkodai-cho, Nada-ku Kobe-sh, Hyogo 13, 〒6570013, JP)
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (1-8-1, Inohana Chuo-ku, Chiba-sh, Chiba 56, 〒2600856, JP)
International Classes:
C07C281/06; A61K31/17; A61K31/175; A61P3/10; C07C337/06
Foreign References:
JP2003211840A2003-07-30
JP2006517199A2006-07-20
JP2005532402A2005-10-27
Other References:
SCOTT, F. L. ET AL.: "Polynitrogen Systems from the Hydrazinocarbonic Acids. V. Aminolytic Reactions of N,N-Diphenylcarbamyl Azide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, 1957, pages 6077 - 6082, XP055491165, ISSN: 0002-7863
PACILLY, CH. C. P.: "The action of aliphatic isocyanates on hydrazine derivatives", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS ET DE LA BELGIQUE, vol. 55, 1936, pages 101 - 121, XP055580225, ISSN: 0370-7539
DATABASE CAS [o] 26 September 2002 (2002-09-26), XP055491207, retrieved from STN Database accession no. 455309-99-6
DATABASE CAS [o] 15 April 2003 (2003-04-15), XP055491210, retrieved from STN Database accession no. 502969-01-9
DATABASE CAS [o] 7 February 1987 (1987-02-07), XP055491214, retrieved from STN Database accession no. 106437-84-7
Attorney, Agent or Firm:
YAMAMOTO, Yoshiki (JCR PHARMACEUTICALS CO. LTD, 3-19, Kasuga-cho, Ashiya-sh, Hyogo 21, 〒6590021, JP)
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