Title:
NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
Document Type and Number:
WIPO Patent Application WO/2005/108338
Kind Code:
A1
Abstract:
The present invention is directed to novel compounds according to formulae (I) wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.
Inventors:
SARSHAR SEPEHR (US)
Application Number:
PCT/US2005/015366
Publication Date:
November 17, 2005
Filing Date:
May 02, 2005
Export Citation:
Assignee:
AUSPEX PHARMACEUTICALS (US)
SARSHAR SEPEHR (US)
SARSHAR SEPEHR (US)
International Classes:
A61K31/12; A61K31/165; A61K31/35; C07C49/115; C07C49/23; C07C49/245; C07C49/255; C07C49/747; C07C49/753; C07C49/76; C07C69/00; C07C69/734; C07C233/00; C07C235/34; C07C323/22; C07C323/62; C07D311/78; C07D319/06; C07D335/04; (IPC1-7): C07C49/115; C07C49/23; C07C49/76; C07C233/00; C07D335/04; C07D311/78; A61K31/35; A61K31/12; A61K31/165
Foreign References:
| US6844466B2 | 2005-01-18 | |||
| US6825233B2 | 2004-11-30 |
Other References:
MUCCIO P.D. ET AL: "Conformationally Defined 6-s-trans-Retinoic Acid Analogs. 3. Structure Activity Relationship for Nuclear Receptor Binding, Transcriptional Activity and Cancer Chemopreventive Activity.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 39, no. 19, September 1996 (1996-09-01), pages 3625 - 3635, XP002921457
ZACHEIS D. ET AL: "Heteroarotinoids Inhibit Head and Neck Cancer Lines in Vivo and in Vitro Through Both RAR and RXR Retinoic Acid Receptors.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 42, 1999, pages 4434 - 4445, XP002278654
ZACHEIS D. ET AL: "Heteroarotinoids Inhibit Head and Neck Cancer Lines in Vivo and in Vitro Through Both RAR and RXR Retinoic Acid Receptors.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 42, 1999, pages 4434 - 4445, XP002278654
Attorney, Agent or Firm:
Haile, Lisa A. (4365 Executive Drive Suite 110, San Diego CA, US)
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