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Patent Searching and Data


Title:
NOVEL THERAPEUTIC TARGET FOR THE TREATMENT OF CANCERS AND RELATED THERAPIES AND METHODS
Document Type and Number:
WIPO Patent Application WO/2014/145817
Kind Code:
A3
Abstract:
Disclosed herein are compositions and methods for treating or preventing certain cancers in a subject. In certain embodiments such compositions and methods generally relate to the use of G-coupled protein receptor 40 (GPR40) agonists to inhibit the growth or induce apoptosis of certain cancer cells. The compositions and related methods disclosed herein may be used to treat subjects affected by cancers, such as melanoma, medullary thyroid carcinoma, malignant peripheral nerve sheath tumors and neuroblastoma, and to reduce the incidence of metastases in such affected subjects.

Inventors:
PUDER MARK (US)
NEHRA DEEPIKA (US)
KALISH BRIAN (US)
Application Number:
PCT/US2014/030646
Publication Date:
December 31, 2014
Filing Date:
March 17, 2014
Export Citation:
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Assignee:
CHILDRENS MEDICAL CENTER (US)
International Classes:
A01N61/00; A01N37/00; A23D7/00; A23D9/00; A61K31/20
Foreign References:
US20070088076A12007-04-19
Other References:
KIM ET AL.: "Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case -control study.", BMC CANCER, vol. 9, 2009, pages 216
HAWCROFT ET AL.: "The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC -26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility.", BR J PHARMACOL., vol. 166, no. 5, 2012, pages 1724 - 37
BARNES ET AL.: "Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib.", PEDIATR RES., vol. 71, no. 2, 2012, pages 168 - 78
Attorney, Agent or Firm:
TREANNIE, Lisa, M. (Barnes-Brown & Pendleton P.C.,230 Third Avenue, 4th Floo, Waltham MA, US)
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