Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/107662
Kind Code:
A1
Abstract:
The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carbosylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

Inventors:
LEE, Jong Seok (605-703, 83 Gamgol-ro, Sangnok-gu,Ansan-si, Gyeonggi-do, 15623, KR)
SUNG, Dan Bi (Floor 2, 21 Seorim 1-gil,Gwanak-gu, Seoul, 08828, KR)
MUN, Bo Hyun (108-1203, 11 Hoguk-ro 429beon-gil, Soheul-eup,Pocheon-si, Gyeonggi-do, 11184, KR)
LEE, Hyi Seung (102-506, 45 Sinbanpo-ro,Seocho-gu, Seoul, 06502, KR)
LEE, Yeon Ju (125-1702, 91 Geumsan-ro,Gunpo-si, Gyeonggi-do, 15815, KR)
LEE, Ji Hoon (901-1604, 32 Ttukseom-ro 34-gil,Gwangjin-gu, Seoul, 05090, KR)
SHIN, Hee Jae (204-802, 45 Geumgok-ro, Gwonseon-gu,Suwon-si, Gyeonggi-do, 16384, KR)
PARK, Sol (404, 7-1 Yonggu-daero 1890beon-gil, Giheung-gu,Yongin-si, Gyeonggi-do, 17074, KR)
Application Number:
KR2017/015585
Publication Date:
June 06, 2019
Filing Date:
December 27, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (787, Haean-ro Sangnok-gu,Ansan-si, Gyeonggi-do, 15627, KR)
International Classes:
C07D495/04; G01N31/22; G01N33/533; G01N33/84
Attorney, Agent or Firm:
NAM & NAM WORLD PATENT & LAW FIRM (3rd Fl, 117 Seosomun-ro,Jung-gu, Seoul, 04515, KR)
Download PDF: