Title:
NOVEL THIOL DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2000/017162
Kind Code:
A1
Abstract:
Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R?1¿s are the same or different and each represents hydrogen, optionally substituted hydrocarbyl, acyl, etc.; X?1¿ represents a bond, optionally substituted divalent aliphatic hydrocarbyl, etc.; X?2¿ represents a bond, optionally substituted divalent aliphatic hydrocarbyl, -O-, etc.; Ys are the same or different and each represents hydrogen, optionally substituted hydrocarbyl, oxo, etc.; m is 0 or 1; n is an integer of 1 to 3; q¿1? is an integer of 1 to 2n+4; and q¿2? is an integer of 0 to 2n+3, provided that q¿1?+q¿2? is 2n+4.
Inventors:
YAMASHITA TOSHIRO (JP)
NARA HIROSHI (JP)
TAKIZAWA MASAYUKI (JP)
YOSHIMURA KOJI (JP)
NARA HIROSHI (JP)
TAKIZAWA MASAYUKI (JP)
YOSHIMURA KOJI (JP)
Application Number:
PCT/JP1999/005103
Publication Date:
March 30, 2000
Filing Date:
September 20, 1999
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
YAMASHITA TOSHIRO (JP)
NARA HIROSHI (JP)
TAKIZAWA MASAYUKI (JP)
YOSHIMURA KOJI (JP)
YAMASHITA TOSHIRO (JP)
NARA HIROSHI (JP)
TAKIZAWA MASAYUKI (JP)
YOSHIMURA KOJI (JP)
International Classes:
A61P19/02; A61P19/10; C07D207/273; C07D207/40; C07D207/416; C07D209/48; C07D211/76; C07D211/78; C07D211/88; C07D401/12; C07D403/12; C07D405/06; C07D405/12; C07D409/12; C07D207/26; (IPC1-7): C07D207/26; A61K31/40; A61K31/44; A61K31/445; A61K31/505; A61K31/535; C07D207/40; C07D211/88; C07D401/12; C07D403/12; C07D405/12; C07D409/12
Foreign References:
| US3855239A | 1974-12-17 | |||
| EP0574758A1 | 1993-12-22 |
Other References:
LOBL THOMAS J. ET AL.: "SV40 large T-antigen nuclear signal analogs: successful nuclear targeting with bovine serum albumin but not low molecular weight fluorescent conjugates", BIOPOLYMERS, vol. 29, no. 1, 1990, pages 197 - 203, XP002935519
See also references of EP 1132379A4
See also references of EP 1132379A4
Attorney, Agent or Firm:
Asahina, Tadao (Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku Osaka-shi Osaka, JP)
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