Title:
NOVEL THYROID HORMONE β RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2021/244582
Kind Code:
A1
Abstract:
The present application provides a novel thyroid hormone β receptor agonist having better activity, selectivity or safety and represented by formula (I), and use thereof in preventing or treating a disease related to the β receptor agonist. The disease comprises, for example, obesity, hyperlipidemia, hypercholesterolemia, diabetes, the liver disease (fatty liver, NASH, NAFLD, etc.), the cardiovascular disease (atherosclerosis, etc.), the thyroid disease (hypothyroidism, thyroid cancer, etc.), etc.
Inventors:
YU YONGGUO (CN)
WANG YIQIAN (CN)
KE ZUNHONG (CN)
WANG YIQIAN (CN)
KE ZUNHONG (CN)
Application Number:
PCT/CN2021/097986
Publication Date:
December 09, 2021
Filing Date:
June 02, 2021
Export Citation:
Assignee:
CHENGDU KANGHONG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D239/34; A61K31/505; A61K31/506; A61P3/04; A61P3/06; A61P5/14; C07D239/02; C07D403/12
Domestic Patent References:
| WO2020073974A1 | 2020-04-16 | |||
| WO2020077123A1 | 2020-04-16 | |||
| WO2002051805A1 | 2002-07-04 |
Foreign References:
| CN102459185A | 2012-05-16 | |||
| CN110627773A | 2019-12-31 | |||
| CN109574995A | 2019-04-05 | |||
| JP2012106996A | 2012-06-07 | |||
| JP2011088840A | 2011-05-06 | |||
| CN101228135A | 2008-07-23 | |||
| CN1882327A | 2006-12-20 | |||
| CN1216857C | 2005-08-31 | |||
| CN102459185A | 2012-05-16 |
Other References:
JOURNAL OF MOLECULAR AND CELLUAR CARDIOLOGY, vol. 37, 2004, pages 1137 - 1146
J. MED. CHEM., vol. 57, 2014, pages 3912 - 3923
J. MED. CHEM., vol. 57, 2014, pages 3912 - 3923
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
Download PDF: