Title:
NOVEL TLR2 ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2016/195194
Kind Code:
A2
Abstract:
The present invention relates to TLR2 antagonists, which are small novel molecules, and, particularly, to: 19 novel TLR2 antagonists; a pharmaceutical composition, containing the antagonists, for preventing or treating inflammatory diseases; and a TLR4 modulator, containing the antagonists. The novel TLR2 antagonists according to the present invention can be effectively used as a preparation for oral administration by having low molecular weight and high oral bioavailability, and can be useful in pharmaceutical compositions for preventing or treating inflammatory diseases since the secretion of IL-8 is effectively inhibited and in vivo cytotoxicity is not induced. In addition, the novel TLR2 antagonists according to the present invention can be used as a TLR4 modulator.
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Inventors:
CHOI SANG DUN (KR)
DURAI PRASANNAVENKATESH (KR)
ACHEK ASMA (KR)
DURAI PRASANNAVENKATESH (KR)
ACHEK ASMA (KR)
Application Number:
PCT/KR2015/014202
Publication Date:
December 08, 2016
Filing Date:
December 23, 2015
Export Citation:
Assignee:
AJOU UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)
International Classes:
C07D211/00; A61K9/00; A61K31/38; A61K31/40; A61K31/4436; A61K31/5377; A61K31/551; A61P17/00; A61P29/00
Other References:
See references of EP 3305767A4
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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