NOVEL TLR4 ANTAGONIST

WIPO Patent Application WO/2016/195159

A1

The present invention relates to a peptide for inhibiting a TLR4 signaling pathway, a TLR4 antagonist comprising the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. More specifically, the present invention relates to a peptide which binds to a TLR4/MD2 composite to inhibit the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs, a TLR4 antagonist comprising the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. The peptide according to the present invention has an excellent effect of inhibiting the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs by inhibiting a TLR4 signaling pathway induced by a liphopolysaccharide (LPS), and thus can be favorably used as a composition for preventing or treating autoimmune diseases and inflammatory diseases occurring by the TLR4 signaling pathway.

JPH10237099	GLYCOLIPID SUGAR CHAIN REPLICA PEPTIDE
WO/2005/087795	USE OF PEPTIDES AS PENETRATING CELL CARRIERS
WO/2015/058258	AΒ MODULATING PEPTIDES

CHOI SANG DUN (KR)
YOO TAE HYEON (KR)
PARK SEOL HEE (KR)

PCT/KR2015/008055

December 08, 2016

July 31, 2015

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AJOU UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)

C07K7/08; C07K14/47

WO2009059143A2	2009-05-07
WO2005065015A2	2005-07-21

KR102110119279A
KR20080065653A	2008-07-14

SVAJGER ET AL.: "Novel Toil-Like Receptor 4 (TLR4) Antagonists Identified by Structure- and Ligaud-based Virtual Screening", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 70, 2013, pages 393 - 399, XP028794169

KIM, SOON WOONG (KR)
김순웅 (KR)

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