Title:
NOVEL TRANSCRIPTION ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2020/032057
Kind Code:
A1
Abstract:
The present invention provides a transcription activator consisting of not more than 200 amino acid sequences and containing VP64 and a transcription activation site of RTA. The present invention also provides a complex of a nucleic acid sequence-recognizing module specifically binding to a target nucleotide sequence in a double-stranded DNA and the transcription activator.
Inventors:
YAMAGATA TETSUYA (US)
QIN YUANBO (US)
QIN YUANBO (US)
Application Number:
PCT/JP2019/030972
Publication Date:
February 13, 2020
Filing Date:
August 06, 2019
Export Citation:
Assignee:
MODALIS THERAPEUTICS CORP (JP)
International Classes:
C07K19/00; C12N15/09; C12N15/62
Domestic Patent References:
| WO2018035503A1 | 2018-02-22 | |||
| WO2002028168A1 | 2002-04-11 | |||
| WO2018169983A1 | 2018-09-20 |
Other References:
CHAVEZ A. ET AL.: "Highly-efficient Cas9-mediated transcriptional programming.", NAT. METHODS., vol. 12, no. 4, 2015, pages 326 - 328, XP055371318, DOI: 10.1038/nmeth.3312
HARDWICK J. ET AL.: "The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16.", J. VIROL., vol. 66, no. 9, 1992, pages 5500 - 5508, XP055683851
KIM E. ET AL.: "In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni.", NATURE COMMUNICATIONS, vol. 8, 2017, pages 14500, XP055435850
See also references of EP 3833758A4
HARDWICK J. ET AL.: "The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16.", J. VIROL., vol. 66, no. 9, 1992, pages 5500 - 5508, XP055683851
KIM E. ET AL.: "In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni.", NATURE COMMUNICATIONS, vol. 8, 2017, pages 14500, XP055435850
See also references of EP 3833758A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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