Title:
NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/106059
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases or tumors, containing, as an active ingredient, a tricyclic compound represented by the following formula 1 or a pharmaceutically acceptable salt thereof, and a health food composition for preventing or alleviating autoimmune diseases or tumors, containing the tricyclic compound as an active ingredient. [Chemical formula 1] A tricyclic compound represented by chemical formula 1 of the present invention has an excellent inhibitory activity against IRAK4, and thus can be effectively used in the prevention, treatment, or alleviation of autoimmune diseases or tumors.
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Inventors:
CHO HEEYEONG (KR)
LIM HEE-JONG (KR)
PARK WOO KYU (KR)
JEONG DAE YOUNG (KR)
KIM HYEON YOUNG (KR)
YOON SAE-BOM (KR)
LEE CHONG OCK (KR)
LEE HEUNG KYOUNG (KR)
HONG VICTOR SUKBONG (KR)
CHOI JI HYE (KR)
LIM HEE-JONG (KR)
PARK WOO KYU (KR)
JEONG DAE YOUNG (KR)
KIM HYEON YOUNG (KR)
YOON SAE-BOM (KR)
LEE CHONG OCK (KR)
LEE HEUNG KYOUNG (KR)
HONG VICTOR SUKBONG (KR)
CHOI JI HYE (KR)
Application Number:
PCT/KR2019/015948
Publication Date:
May 28, 2020
Filing Date:
November 20, 2019
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D487/04; A23L29/00; A23L33/10; A61K31/519; A61P35/00; A61P37/00
Domestic Patent References:
| WO2014011902A1 | 2014-01-16 | |||
| WO2015161373A1 | 2015-10-29 | |||
| WO2015131005A1 | 2015-09-03 | |||
| WO2010006032A1 | 2010-01-14 | |||
| WO2012129258A1 | 2012-09-27 | |||
| WO2013066729A1 | 2013-05-10 | |||
| WO2013106612A1 | 2013-07-18 | |||
| WO2017033093A1 | 2017-03-02 | |||
| WO2006111648A1 | 2006-10-26 | |||
| WO2010025872A2 | 2010-03-11 |
Foreign References:
| US8618121B2 | 2013-12-31 | |||
| CN108676009A | 2018-10-19 |
Other References:
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 9, 2009, pages 724 - 737
J. EXP. MED., vol. 212, 2015, pages 2189 - 2201
J IMMUNOL, vol. 186, 2011, pages 1279 - 1288
BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 3211 - 3214,3291-3295,3656-3660
BIOORG. MED. CHEM. LETT., vol. 27, 2017, pages 2721 - 2726
ADV. SYNTH. CATAL., vol. 352, 2010, pages 1033 - 1038
BIOORG. MED CHEM., vol. 20, 2012, pages 6123
TETRAHEDRON, vol. 65, 2009, pages 5427 - 5437
BIOORG. MED CHEM.LETT., vol. 13, 2003, pages 2003 - 2007
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 2004, pages 785 - 791
J. EXP. MED., vol. 212, 2015, pages 2189 - 2201
J IMMUNOL, vol. 186, 2011, pages 1279 - 1288
BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 3211 - 3214,3291-3295,3656-3660
BIOORG. MED. CHEM. LETT., vol. 27, 2017, pages 2721 - 2726
ADV. SYNTH. CATAL., vol. 352, 2010, pages 1033 - 1038
BIOORG. MED CHEM., vol. 20, 2012, pages 6123
TETRAHEDRON, vol. 65, 2009, pages 5427 - 5437
BIOORG. MED CHEM.LETT., vol. 13, 2003, pages 2003 - 2007
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 2004, pages 785 - 791
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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