Title:
NOVEL TUMOR DETECTION MARKER TAGME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/060775
Kind Code:
A1
Abstract:
Provided are a tumor detection marker TAGMe and use thereof. On the basis of analysis and research on a large number of clinical samples, novel DNA methylation tumor markers are obtained by separation. The markers are in a low methylation state in a normal tissue and in a high methylation state in a tumor sample, and show a significant difference in the methylation state in a patient with a tumor, and the difference is statistically significant. The markers have a more excellent effect when they are used in combination for detection. The tumor markers can be used as markers for diagnosis, screening, typing, detection, and prognosis of a clinical tumor, can also be used as novel molecules for clinical auxiliary diagnosis or prognosis of a tumor, or can be used for designing a diagnostic reagent and kit.
Inventors:
LI ZHENYAN (CN)
DONG SHIHUA (CN)
MAO ZHANRUI (CN)
DONG SHIHUA (CN)
MAO ZHANRUI (CN)
Application Number:
PCT/CN2023/104682
Publication Date:
March 28, 2024
Filing Date:
June 30, 2023
Export Citation:
Assignee:
SHANGHAI EPIPROBE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N15/12; C12N15/11; C12Q1/6851; C12Q1/6869; C12Q1/6886
Domestic Patent References:
| WO2020251851A2 | 2020-12-17 |
Foreign References:
| CN115725591A | 2023-03-03 | |||
| CN109069670A | 2018-12-21 | |||
| CN110257525A | 2019-09-20 | |||
| US20210340627A1 | 2021-11-04 |
Other References:
DATABASE Nucleotide 25 January 2021 (2021-01-25), ANONYMOUS : "Homo sapiens T-box transcription factor 5 (TBX5), RefSeqGene (LRG_670) on chromosome 12", XP093150006, retrieved from NCBI Database accession no. NG_007373.1
DATABASE Nucleotide 29 June 2000 (2000-06-29), ANONYMOUS : "Homo sapiens chromosome 12 clone RP11-17F13, complete sequence", XP093150013, retrieved from NCBI Database accession no. AC068811.8
DATABASE Nucleotide 29 June 2000 (2000-06-29), ANONYMOUS : "Homo sapiens chromosome 12 clone RP11-17F13, complete sequence", XP093150013, retrieved from NCBI Database accession no. AC068811.8
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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