NOVEL TUMOR MARKERS

WIPO Patent Application WO/2011/073901

A8

The present invention relates to a tumor marker or group of tumor markers associated with the progression of a neoplastic disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a neoplastic disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing, graduating, monitoring or prognosticating a neoplastic disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a neoplastic disease therapy as well as to a pharmaceutical composition based on the inhibition of the expression of said tumor markers.

HOFFMANN RALF (DE)
VISSER HUGO MATTHIEU (GB)
ROMIJN EDWIN PETER (NL)
WAANDERS LEONIE (NL)
MERKLE DENNIS (NL)
HULSEN TIM (NL)

PCT/IB2010/055801

December 08, 2011

December 14, 2010

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KONINKL PHILIPS ELECTRONICS NV (NL)
HOFFMANN RALF (DE)
VISSER HUGO MATTHIEU (GB)
ROMIJN EDWIN PETER (NL)
WAANDERS LEONIE (NL)
MERKLE DENNIS (NL)
HULSEN TIM (NL)

G01N33/574

KROEZE, John et al. (AE Eindhoven, NL)

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