NOVEL TWO-PHOTON ABSORBING FLUORESCENT SUBSTANCE AND CELL IMAGING METHOD USING SAME

Title:

NOVEL TWO-PHOTON ABSORBING FLUORESCENT SUBSTANCE AND CELL IMAGING METHOD USING SAME

Document Type and Number:

WIPO Patent Application WO/2016/047882

Kind Code:

A1

Abstract:

The present invention relates to a novel one-photon or two-photon absorbing fluorescent compound, a method for preparing the same, and a cell imaging method using the same and, more specifically, to a novel two-photon absorbing fluorescent compound which has a higher fluorescence quantum yield and higher absorption cross section value than an existing two-photon absorbing fluorescent substance, acedan, and thus can be excellently applied to biological imaging. The compound according to the present invention can be usefully used in the development of a novel D-π-A type fluorescent substance.

Inventors:

AHN KYO HAN (KR)
MOON HYUNSOO (KR)
KIM DOKYOUNG (KR)
SINGHA SUBHANKAR (KR)
ROY BASAB (KR)
SAMBASIVAN SUNDERRAMAN (KR)

Application Number:

PCT/KR2015/004508

Publication Date:

March 31, 2016

Filing Date:

May 06, 2015

Export Citation:

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Assignee:

POSTECH ACAD IND FOUND (KR)

International Classes:

C07D225/02; A61K49/06; A61K49/10

Foreign References:

JPS462154B1	1971-01-20
KR20010087399A	2001-09-15

Other References:

ANDREJ PETRIC ET AL.: "Dicyanovinylnaphthalenes for neuroimaging of amyloids and relationships of electronic structures and geometries to binding affinities", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ARERICA, vol. 109, 2012, pages 16492 - 16497
SUNG MIN SHIN ET AL.: "Assessing the guest-accessible volume in MOFs using two-photon fluorescence microscopy", CHEM COMMUN., vol. 50, 2014, pages 289 - 291, [retrieved on 20130731]
ALLA SREENIVASA RAO ET AL.: "Studies on acedan-based mononuclear zinc complexes toward selective fluorescent probes for pyrophosphate", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, 2012, pages 8410 - 8417