NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES

Title:

NOVEL UNSATURATED TETRACYCLIC TETRAHYDROFURAN DERIVATIVES

Document Type and Number:

WIPO Patent Application WO2006000555

Kind Code:

A3

Abstract:

This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT_2A and 5-HT_2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I), and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.

Inventors:

CID-NUNEZ JOSE MARIA (ES)
MEGENS ANTONIUS ADRIANUS HENDR (BE)
TRABANCO-SUAREZ ANDRES AVELINO (ES)

Application Number:

PCT/EP2005/052891

Publication Date:

August 17, 2006

Filing Date:

June 21, 2005

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NV (BE)
CID-NUNEZ JOSE MARIA (ES)
MEGENS ANTONIUS ADRIANUS HENDR (BE)
TRABANCO-SUAREZ ANDRES AVELINO (ES)

International Classes:

C07D493/04; A61K31/34; C07D491/04; C07D495/04; C07D495/16

Domestic Patent References:

WO1999019317A1	1999-04-22
WO1997038991A1	1997-10-23

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