Title:
NOVEL UREA-BASED OR CARBAMATE-BASED P2X7 RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MAJOR DEPRESSIVE DISORDER, COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/090853
Kind Code:
A1
Abstract:
The present invention relates to a novel urea-based or carbamate-based P2X7 receptor antagonist compound. The novel urea-based or carbamate-based P2X7 receptor antagonist compound according to the present invention can effectively inhibit the activity of P2X7R, and it is expected that major depressive disorder can be ultimately prevented or treated using a pharmaceutical composition comprising the compound.
Inventors:
BYUN YOUNG JOO (KR)
LEE SHIN YOUNG (KR)
HA HYUN SOO (KR)
HAM BYUNG JOO (KR)
HWANG JONG IK (KR)
HURH SUNG HOON (KR)
NGUYEN PHUONG LAN (VN)
LEE SHIN YOUNG (KR)
HA HYUN SOO (KR)
HAM BYUNG JOO (KR)
HWANG JONG IK (KR)
HURH SUNG HOON (KR)
NGUYEN PHUONG LAN (VN)
Application Number:
PCT/KR2022/018104
Publication Date:
May 25, 2023
Filing Date:
November 16, 2022
Export Citation:
Assignee:
UNIV KOREA RES & BUSINESS FOUNDATION SEJONG CAMPUS (KR)
UNIV KOREA RES & BUS FOUND (KR)
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07D207/277; A61K31/17; A61K31/4015; A61K31/427; A61K31/4439; A61K31/45; A61P25/24; C07D211/74; C07D401/12; C07D417/12
Domestic Patent References:
| WO2000009125A1 | 2000-02-24 |
Foreign References:
| US20020007075A1 | 2002-01-17 |
Other References:
SPERLÁGH BEÁTA, ILLES PETER: "P2X7 receptor: an emerging target in central nervous system diseases", TRENDS IN PHARMACOLOGICAL SCIENCES., ELSEVIER, HAYWARTH., GB, vol. 35, no. 10, 1 October 2014 (2014-10-01), GB , pages 537 - 547, XP093068158, ISSN: 0165-6147, DOI: 10.1016/j.tips.2014.08.002
DATABASE Registry 20 June 2016 (2016-06-20), ANONYMOUS : "1-Pyrrolidinecarboxamid e, 3-oxo-N-(phenylm ethyl)-", XP093068160, Database accession no. 1935052-67-7
DATABASE Registry CAS; 17 June 2019 (2019-06-17), ANONYMOUS : "1,2-Pyrrolidinedicarboxa mide, N1-(phenylme thyl)-N2-(3-pyridinyl methyl)-, (2S)-", XP093068162, Database accession no. 2337078-72-3
BRUFFAERTS JEFFREY, VON WOLFF NIKLAS, DISKIN-POSNER YAEL, BEN-DAVID YEHOSHOA, MILSTEIN DAVID: "Formamides as Isocyanate Surrogates: A Mechanistically Driven Approach to the Development of Atom-Efficient, Selective Catalytic Syntheses of Ureas, Carbamates, and Heterocycles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 41, 16 October 2019 (2019-10-16), pages 16486 - 16493, XP055898375, ISSN: 0002-7863, DOI: 10.1021/jacs.9b08942
DATABASE Registry 20 June 2016 (2016-06-20), ANONYMOUS : "1-Pyrrolidinecarboxamid e, 3-oxo-N-(phenylm ethyl)-", XP093068160, Database accession no. 1935052-67-7
DATABASE Registry CAS; 17 June 2019 (2019-06-17), ANONYMOUS : "1,2-Pyrrolidinedicarboxa mide, N1-(phenylme thyl)-N2-(3-pyridinyl methyl)-, (2S)-", XP093068162, Database accession no. 2337078-72-3
BRUFFAERTS JEFFREY, VON WOLFF NIKLAS, DISKIN-POSNER YAEL, BEN-DAVID YEHOSHOA, MILSTEIN DAVID: "Formamides as Isocyanate Surrogates: A Mechanistically Driven Approach to the Development of Atom-Efficient, Selective Catalytic Syntheses of Ureas, Carbamates, and Heterocycles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 41, 16 October 2019 (2019-10-16), pages 16486 - 16493, XP055898375, ISSN: 0002-7863, DOI: 10.1021/jacs.9b08942
Attorney, Agent or Firm:
KWAK, Jai Gun et al. (KR)
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