Title:
NOVEL USE OF LIVER X RECEPTOR AGONISTS
Document Type and Number:
WIPO Patent Application WO2004058175
Kind Code:
A3
Abstract:
This invention provides novel methods for modulating expression of glut4 and other genes involved in glucose metabolism, and methods for treating or ameliorating diabetes and related diseases. The methods comprise administering to cells in a subject an effective amount of an LXR agonist and thereby modulating expression of those genes that are important for glucose uptake or gluconeogenesis. The modulation will lead to increased uptake of glucose by cells in the subject and/or reduced glucose output in the liver, and accordingly ameliorate symptoms associated with, e.g., type IIdiabetes.
Inventors:
SAEZ ENRIQUE (US)
TONTONOZ PETER (US)
LAFFITTE BRYAN A (US)
LI JING (US)
TONTONOZ PETER (US)
LAFFITTE BRYAN A (US)
LI JING (US)
Application Number:
PCT/US2003/040906
Publication Date:
September 10, 2004
Filing Date:
December 22, 2003
Export Citation:
Assignee:
IRM LLC (BM)
UNIV CALIFORNIA (US)
SAEZ ENRIQUE (US)
TONTONOZ PETER (US)
LAFFITTE BRYAN A (US)
LI JING (US)
UNIV CALIFORNIA (US)
SAEZ ENRIQUE (US)
TONTONOZ PETER (US)
LAFFITTE BRYAN A (US)
LI JING (US)
International Classes:
A01N41/06; A61K48/00; C12N5/08; C12N15/85; C12Q1/68; G01N33/53; G01N33/566; A61K; (IPC1-7): A01N41/06; G01N33/53
Foreign References:
| US6316503B1 | 2001-11-13 | |||
| US20030073614A1 | 2003-04-17 | |||
| US20020048572A1 | 2002-04-25 | |||
| GB2381866A | 2003-05-14 |
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