Title:
NOVEL USE OF MELANOCORTIN-1 RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2023/145959
Kind Code:
A1
Abstract:
A medicine for treating or preventing interstitial lung disease and the disease or symptoms associated with systemic scleroderma in a subject, said medicine containing, as an active ingredient, 1-\{2-[(3S,4R)-1-\{[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-yl]carbonyl\}-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl\}piperidine-4-carboxylic acid, a pharmaceutically acceptable salt thereof or a co-crystal thereof.
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Inventors:
KONDO MASAHIRO (JP)
SUZUKI TSUYOSHI (JP)
KAWANO YUKO (JP)
SUZUKI TSUYOSHI (JP)
KAWANO YUKO (JP)
Application Number:
PCT/JP2023/003001
Publication Date:
August 03, 2023
Filing Date:
January 31, 2023
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
A61K31/454; A61P1/00; A61P9/12; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P43/00; C12N15/12; C12Q1/6837; G01N33/50; G01N33/68
Domestic Patent References:
| WO2020138481A1 | 2020-07-02 | |||
| WO2021251452A1 | 2021-12-16 |
Other References:
DINPARASTISALEH ROSHAN, MIRSAEIDI MEHDI: "Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player", PHARMACEUTICALS, vol. 14, no. 1, pages 45, XP093080554, DOI: 10.3390/ph14010045
KOKOT AGATHA, SINDRILARU ANCA, SCHILLER MEINHARD, SUNDERKÖTTER CORD, KERKHOFF CLAUS, ECKES BEATE, SCHARFFETTER-KOCHANEK KARIN, LUG: "α-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?", ARTHRITIS& RHEUMATISM, WILEY INTERSCIENCE, US, vol. 60, no. 2, 1 February 2009 (2009-02-01), US , pages 592 - 603, XP093080557, ISSN: 0004-3591, DOI: 10.1002/art.24228
COLOMBO GUALTIERO, GATTI STEFANO, SORDI ANDREA, TURCATTI FLAVIA, CARLIN ANDREA, ROSSI CLAUDIA, LONATI CATERINA, CATANIA ANNA: "PRODUCTION AND EFFECTS OF α-MELANOCYTE-STIMULATING HORMONE DURING ACUTE LUNG INJURY", SHOCK, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 27, no. 3, 1 March 2007 (2007-03-01), US , pages 326 - 333, XP093080563, ISSN: 1073-2322, DOI: 10.1097/01.shk.0000239764.80033.7e
SUZUKA TAKAYASU ET AL.: "O-53-4: Intravenous administration of adipose tissue-derived stem cells suppresses skin inflammation and fibrosis in mice with bleomycin-induced skin sclerosis.", PROGRAMS AND ABSTRACTS OF THE 17TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE; MARCH 21-23, 2018, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, 1 January 2018 (2018-01-01) - 23 March 2018 (2018-03-23), JP, pages 252, XP009548076
KONDO MASAHIRO, SUZUKI TSUYOSHI, KAWANO YUKO, KOJIMA SHINJI, MIYASHIRO MASAHIKO, MATSUMOTO ATSUHIRO, KANIA GABRIELA, BŁYSZCZUK PRZ: "Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis", ARTHRITIS RESEARCH & THERAPY, vol. 24, no. 1, XP093080578, DOI: 10.1186/s13075-022-02899-3
KONDO M., SUZUKI T., KAWANO Y., KOJIMA S., MIYASHIRO M., MATSUMOTO A., KANIA G., BLYSZCZUK P., ROSS R., MULIPA P., DEL GALDO F., Z: "POS0467 DERSIMELAGON, A NOVEL ORAL MELANOCORTIN 1 RECEPTOR AGONIST, DEMONSTRATES DISEASE-MODIFYING EFFECTS IN PRECLINICAL MODELS OF SYSTEMIC SCLEROSIS", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, GB, vol. 81, no. Suppl 1, 1 June 2022 (2022-06-01), GB , pages 488, XP093080582, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2022-eular.29
KOKOT AGATHA, SINDRILARU ANCA, SCHILLER MEINHARD, SUNDERKÖTTER CORD, KERKHOFF CLAUS, ECKES BEATE, SCHARFFETTER-KOCHANEK KARIN, LUG: "α-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?", ARTHRITIS& RHEUMATISM, WILEY INTERSCIENCE, US, vol. 60, no. 2, 1 February 2009 (2009-02-01), US , pages 592 - 603, XP093080557, ISSN: 0004-3591, DOI: 10.1002/art.24228
COLOMBO GUALTIERO, GATTI STEFANO, SORDI ANDREA, TURCATTI FLAVIA, CARLIN ANDREA, ROSSI CLAUDIA, LONATI CATERINA, CATANIA ANNA: "PRODUCTION AND EFFECTS OF α-MELANOCYTE-STIMULATING HORMONE DURING ACUTE LUNG INJURY", SHOCK, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 27, no. 3, 1 March 2007 (2007-03-01), US , pages 326 - 333, XP093080563, ISSN: 1073-2322, DOI: 10.1097/01.shk.0000239764.80033.7e
SUZUKA TAKAYASU ET AL.: "O-53-4: Intravenous administration of adipose tissue-derived stem cells suppresses skin inflammation and fibrosis in mice with bleomycin-induced skin sclerosis.", PROGRAMS AND ABSTRACTS OF THE 17TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE; MARCH 21-23, 2018, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, 1 January 2018 (2018-01-01) - 23 March 2018 (2018-03-23), JP, pages 252, XP009548076
KONDO MASAHIRO, SUZUKI TSUYOSHI, KAWANO YUKO, KOJIMA SHINJI, MIYASHIRO MASAHIKO, MATSUMOTO ATSUHIRO, KANIA GABRIELA, BŁYSZCZUK PRZ: "Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis", ARTHRITIS RESEARCH & THERAPY, vol. 24, no. 1, XP093080578, DOI: 10.1186/s13075-022-02899-3
KONDO M., SUZUKI T., KAWANO Y., KOJIMA S., MIYASHIRO M., MATSUMOTO A., KANIA G., BLYSZCZUK P., ROSS R., MULIPA P., DEL GALDO F., Z: "POS0467 DERSIMELAGON, A NOVEL ORAL MELANOCORTIN 1 RECEPTOR AGONIST, DEMONSTRATES DISEASE-MODIFYING EFFECTS IN PRECLINICAL MODELS OF SYSTEMIC SCLEROSIS", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, GB, vol. 81, no. Suppl 1, 1 June 2022 (2022-06-01), GB , pages 488, XP093080582, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2022-eular.29
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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