Title:
NOVEL USE OF PHYTOSTENONE
Document Type and Number:
WIPO Patent Application WO/2020/045542
Kind Code:
A1
Abstract:
According to the present invention, a transdermal absorbent for reducing a subcutaneous fat is provided, which comprises phytostenone. Accordingly, a method for further reducing a subcutaneous fat can be provided.
Inventors:
INOUE NAO (JP)
NAGASHIMA TADASHI (JP)
NAGASHIMA TADASHI (JP)
Application Number:
PCT/JP2019/033822
Publication Date:
March 05, 2020
Filing Date:
August 29, 2019
Export Citation:
Assignee:
INOUE NAO (JP)
DAISANKASEI CO LTD (JP)
DAISANKASEI CO LTD (JP)
International Classes:
A61K31/575; A61K8/63; A61P3/04; A61Q19/00
Foreign References:
| JP2001240544A | 2001-09-04 | |||
| JP2001240544A | 2001-09-04 | |||
| JP2003048837A | 2003-02-21 | |||
| JP2011051939A | 2011-03-17 | |||
| JP2007284348A | 2007-11-01 | |||
| JP2018161943A | 2018-10-18 |
Other References:
KUNIO SUZUKI , RIE KONNO , TAKKESHI SHIMIZU , TADASHI NAGASHIMA , AKIHIKO KIMURA : "A fermentation product of phytosterol including campestenone reduces body fat storage and body weight gain in mice", JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, vol. 53, no. 1, 1 January 2007 (2007-01-01), pages 63 - 67, XP055690942, ISSN: 0301-4800
IKEDA I; KONNO R; SHIMIZU T; IDE T; TAKAHASHI N; KAWADA T; NAGAO K; INOUE N; YANAGITA T; HAMADA T; MORINAGA Y; TOMOYORI H; IMAIZUM: "Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats", BIOCHIMICA ET BIOPHYSICA ACTA , vol. 1760, no. 5, 1 May 2006 (2006-05-01), pages 800 - 807, XP025015031, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2006.02.017
SUZUKI KUNIO : "Lipid metabolism control agent (5-campestenone)", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 61, no. S6, 30 November 2002 (2002-11-30), pages 698 - 703, XP009526165, ISSN: 0047-1852
JEFFREY J BERTI , JAMES J LIPSKY: "Transcutaneous drug delivery: a practical review", MAYO CLINIC PROCEEDINGS, vol. 70, no. 6, 1 June 1995 (1995-06-01), pages 581 - 586, XP009526177, ISSN: 0025-6196, DOI: 10.4065/70.6.581
CAROLE RIBET; EMILIE MONTASTIER; CARINE VALLE; VéRONIC BEZAIRE; ANNE MAZZUCOTELLI; ALINE MAIRAL; NATHALIE VIGUERIE; DOMINIQUE L: "Peroxisome proliferator- activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes", ENDOCRINOLOGY, vol. 151, no. 1, 1 January 2010 (2010-01-01), pages 123 - 133, XP055690944, ISSN: 0013-7227, DOI: 10.1210/en.2009-0726
KUNIO SUZUKI ET AL., NIPPON RINSHO, vol. 61, no. 6, 2003, pages 698 - 703
KUNIO SUZUKI ET AL., J. NUTR. SCI. VITAMINOL., vol. 53, 2007, pages 63 - 67
JOURNAL OF JAPAN SOCIETY FOR THE STUDY OF OBESITY, vol. 13, no. 3, 2007, pages 244 - 249
J. NUTR. SCI. VITAMINOL, vol. 53, 2006, pages 63 - 67
PARISH E.J. ET AL., SYNTHETIC COMMUNICATIONS, vol. 22, 1992, pages 2839
See also references of EP 3845232A4
IKEDA I; KONNO R; SHIMIZU T; IDE T; TAKAHASHI N; KAWADA T; NAGAO K; INOUE N; YANAGITA T; HAMADA T; MORINAGA Y; TOMOYORI H; IMAIZUM: "Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats", BIOCHIMICA ET BIOPHYSICA ACTA , vol. 1760, no. 5, 1 May 2006 (2006-05-01), pages 800 - 807, XP025015031, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2006.02.017
SUZUKI KUNIO : "Lipid metabolism control agent (5-campestenone)", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 61, no. S6, 30 November 2002 (2002-11-30), pages 698 - 703, XP009526165, ISSN: 0047-1852
JEFFREY J BERTI , JAMES J LIPSKY: "Transcutaneous drug delivery: a practical review", MAYO CLINIC PROCEEDINGS, vol. 70, no. 6, 1 June 1995 (1995-06-01), pages 581 - 586, XP009526177, ISSN: 0025-6196, DOI: 10.4065/70.6.581
CAROLE RIBET; EMILIE MONTASTIER; CARINE VALLE; VéRONIC BEZAIRE; ANNE MAZZUCOTELLI; ALINE MAIRAL; NATHALIE VIGUERIE; DOMINIQUE L: "Peroxisome proliferator- activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes", ENDOCRINOLOGY, vol. 151, no. 1, 1 January 2010 (2010-01-01), pages 123 - 133, XP055690944, ISSN: 0013-7227, DOI: 10.1210/en.2009-0726
KUNIO SUZUKI ET AL., NIPPON RINSHO, vol. 61, no. 6, 2003, pages 698 - 703
KUNIO SUZUKI ET AL., J. NUTR. SCI. VITAMINOL., vol. 53, 2007, pages 63 - 67
JOURNAL OF JAPAN SOCIETY FOR THE STUDY OF OBESITY, vol. 13, no. 3, 2007, pages 244 - 249
J. NUTR. SCI. VITAMINOL, vol. 53, 2006, pages 63 - 67
PARISH E.J. ET AL., SYNTHETIC COMMUNICATIONS, vol. 22, 1992, pages 2839
See also references of EP 3845232A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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