Title:
NOVEL USE OF RAGE POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2007/102410
Kind Code:
A1
Abstract:
The object is to provide: a method for screening of a therapeutic or prophylactic agent for a disease associated with a gram-negative bacterium; a method for detection of a gram-negative bacterium; a method for collection of a gram-negative bacterium; and a therapeutic or prophylactic agent for LPS shock. Disclosed are: a method for evaluating the effectiveness of a substance of interest as a therapeutic or prophylactic agent for a disease associated with a gram-negative bacterium, based on the effect of the substance on the binding between RAGE polypeptide and lipopolysaccharide; a method for detecting a gram-negative bacterium in a sample, which comprises contacting RAGE polypeptide with the sample and determining a bacterium as a gram-negative bacterium when the bacterium is bound to RAGE polypeptide; a method for collecting a gram-negative bacterium from a sample, which comprises contacting RAGE polypeptide with the sample to cause the binding between a gram-negative bacterium contained in the sample and RAGE polypeptide; and a therapeutic or prophylactic agent for LPS shock, which comprises RAGE polypeptide.
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Inventors:
YAMAMOTO HIROSHI (JP)
YONEKURA HIDETO (JP)
WATANABE TAKUO (JP)
YAMAMOTO YASUHIKO (JP)
HARASHIMA AI (JP)
KARASAWA TADAHIRO (JP)
TSUNEYAMA KOICHI (JP)
YONEKURA HIDETO (JP)
WATANABE TAKUO (JP)
YAMAMOTO YASUHIKO (JP)
HARASHIMA AI (JP)
KARASAWA TADAHIRO (JP)
TSUNEYAMA KOICHI (JP)
Application Number:
PCT/JP2007/053979
Publication Date:
September 13, 2007
Filing Date:
February 23, 2007
Export Citation:
Assignee:
UNIV KANAZAWA NAT UNIV CORP (JP)
YAMAMOTO HIROSHI (JP)
YONEKURA HIDETO (JP)
WATANABE TAKUO (JP)
YAMAMOTO YASUHIKO (JP)
HARASHIMA AI (JP)
KARASAWA TADAHIRO (JP)
TSUNEYAMA KOICHI (JP)
YAMAMOTO HIROSHI (JP)
YONEKURA HIDETO (JP)
WATANABE TAKUO (JP)
YAMAMOTO YASUHIKO (JP)
HARASHIMA AI (JP)
KARASAWA TADAHIRO (JP)
TSUNEYAMA KOICHI (JP)
International Classes:
C12Q1/02; A61K38/00; A61P29/00; A61P31/04; G01N33/15; G01N33/50; G01N33/569; C07K14/705
Domestic Patent References:
| WO2002092004A2 | 2002-11-21 |
Other References:
BIERHAUS A. ET AL.: "Understanding RAGE, the receptor for advanced glycation end products", J. MOLECULAR MEDICINE, vol. 83, no. 11, 2005, pages 876 - 886, XP019320298
PARESCE D.M. ET AL.: "Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor", NEURON., vol. 17, no. 3, 1996, pages 553 - 565, XP002063322
OHGAMI N. ET AL.: "AGE to AGE Juyotai", SEIKAGAKU, vol. 73, no. 3, 2001, pages 200 - 204, XP003017672
PEISER L. ET AL.: "Scavenger receptors in innate immunity", CURR. OPIN. IMMUNOL., vol. 14, no. 1, 2002, pages 123 - 128, XP004332744
USHIMA M. ET AL.: "LPS Yuhatsu Endotoxin Kessho Mouse ni Okeru RAGE Toyo no Koka", THE JOURNAL OF THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE, vol. 9, no. SUPPL., 31 January 2002 (2002-01-31), pages 166 + ABSTR. NO. P-D-283, XP003017673
IWASAKA H.: "Shock ni Okeru Signal Dentatsu Kiko - HMGB1 o Chushin ni -", ICU & CCU (JAPANESE JOURNAL OF INTENSIVE CARE MEDICINE), vol. 29, no. 12, 10 December 2005 (2005-12-10), pages 1025 - 1032, XP003017674
SCHMIDT A.M. ET AL.: "The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses", J. CLIN. INVEST., vol. 108, no. 7, 2001, pages 949 - 955, XP002994307
LOTZE M.T. ET AL.: "High-mobility group box1 protein (HMGB1): nuclear weapon in the immune arsenal", NATURE REVIEWS IMMUNOLOGY, vol. 5, no. 4, 2005, pages 331 - 342, XP009054524
HARASHIMA A. ET AL.: "Lipopolysaccharide (LPS) induction of septic shock is mediated by its interaction with the receptor for advanced glycation endproducts (RAGE)", 20TH IUBMB INTERNATIONAL CONGRESS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY AND 11TH FAOBMB CONGRESS SHOROKU CD, 3 October 2006 (2006-10-03), pages ABSTR. NO. 3P-C-175, XP003017675
YAMAMOTO Y. ET AL.: "Septic shock ni Okeru Toka Tanpakushitsu Juyotai RAGE no Yakuwari no Shinhakken", JAPANESE JOURNAL OF BACTERIOLOGY, vol. 61, no. 1, 25 February 2006 (2006-02-25), pages 152 + ABSTR. NO. 111-G-22, XP003017676
PARESCE D.M. ET AL.: "Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor", NEURON., vol. 17, no. 3, 1996, pages 553 - 565, XP002063322
OHGAMI N. ET AL.: "AGE to AGE Juyotai", SEIKAGAKU, vol. 73, no. 3, 2001, pages 200 - 204, XP003017672
PEISER L. ET AL.: "Scavenger receptors in innate immunity", CURR. OPIN. IMMUNOL., vol. 14, no. 1, 2002, pages 123 - 128, XP004332744
USHIMA M. ET AL.: "LPS Yuhatsu Endotoxin Kessho Mouse ni Okeru RAGE Toyo no Koka", THE JOURNAL OF THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE, vol. 9, no. SUPPL., 31 January 2002 (2002-01-31), pages 166 + ABSTR. NO. P-D-283, XP003017673
IWASAKA H.: "Shock ni Okeru Signal Dentatsu Kiko - HMGB1 o Chushin ni -", ICU & CCU (JAPANESE JOURNAL OF INTENSIVE CARE MEDICINE), vol. 29, no. 12, 10 December 2005 (2005-12-10), pages 1025 - 1032, XP003017674
SCHMIDT A.M. ET AL.: "The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses", J. CLIN. INVEST., vol. 108, no. 7, 2001, pages 949 - 955, XP002994307
LOTZE M.T. ET AL.: "High-mobility group box1 protein (HMGB1): nuclear weapon in the immune arsenal", NATURE REVIEWS IMMUNOLOGY, vol. 5, no. 4, 2005, pages 331 - 342, XP009054524
HARASHIMA A. ET AL.: "Lipopolysaccharide (LPS) induction of septic shock is mediated by its interaction with the receptor for advanced glycation endproducts (RAGE)", 20TH IUBMB INTERNATIONAL CONGRESS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY AND 11TH FAOBMB CONGRESS SHOROKU CD, 3 October 2006 (2006-10-03), pages ABSTR. NO. 3P-C-175, XP003017675
YAMAMOTO Y. ET AL.: "Septic shock ni Okeru Toka Tanpakushitsu Juyotai RAGE no Yakuwari no Shinhakken", JAPANESE JOURNAL OF BACTERIOLOGY, vol. 61, no. 1, 25 February 2006 (2006-02-25), pages 152 + ABSTR. NO. 111-G-22, XP003017676
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
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