NOVEL USE OF TRICYCLIC COMPOUND

WIPO Patent Application WO/2003/024441

A1

A medicinal composition which exasperates apo AI expression as a remedy for circulatory diseases based on the HDL function enhancement. It is an apo AI expression accelerator which contains a compound represented by the formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a solvate of these: (I) wherein X¹ and X² each independently is optionally substituted aryl or heteroaryl, hydrogen, halogeno, etc.&semi ring A is a benzene ring or six−membered aromatic heterocycle containing one to three nitrogen atoms, the rings each being optionally fused with other aromatic ring, and R¹ to R⁴ each independently is hydrogen, halogeno, lower alkyl, lower alkoxy, etc.

ISHIZUKA NATSUKI (JP)
SAKAI KATSUNORI (JP)
HAYASHI KUNIO (JP)

PCT/JP2001/007979

March 27, 2003

September 14, 2001

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SHIONOGI & CO (JP)
ISHIZUKA NATSUKI (JP)
SAKAI KATSUNORI (JP)
HAYASHI KUNIO (JP)

A61K31/15; A61K31/155; A61K31/357; A61K31/40; A61K31/426; A61K31/44; A61K31/4402; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/47; A61K31/495; A61K31/4965; A61K31/498; A61K31/50; A61K31/502; A61K31/505; A61K31/53; A61P3/06; A61P9/10; C07D213/16; C07D213/30; C07D213/40; C07D213/64; C07D215/04; C07D237/08; C07D237/12; C07D237/14; C07D239/26; C07D239/52; C07D241/12; C07D241/42; C07D251/30; C07D257/04; C07D277/22; C07D277/24; C07D319/20; C07D401/10; C07D405/10; C07D409/04; C07D409/10; (IPC1-7): A61K31/15; A61K31/155; A61K31/50; A61K31/505; A61K31/44; A61K31/4402; A61K31/4965; A61K31/502; A61K31/498; A61K31/47; A61K31/53; A61K31/40; A61K31/426; A61K31/4436; A61K31/4433; A61K31/4439; A61K31/357; A61K31/495; A61P3/06; A61P9/10; C07C259/14; C07D237/14; C07D239/26; C07D213/16; C07D241/12; C07D237/30; C07D409/04; C07D241/42; C07D215/04; C07D213/64; C07D239/52; C07D237/12; C07D237/16; C07D257/04; C07D277/22; C07D409/10; C07D405/10; C07D401/10; C07D213/30; C07D319/20; C07D295/22

JP2001335476A	2001-12-04
JP2001131151A	2001-05-15
JP2001233767A	2001-08-28
JP2000281654A	2000-10-10
EP1024134A1	2000-08-02
JP2000204091A	2000-07-25
JP2001089452A	2001-04-03
US5204351A	1993-04-20
JP2001510477A	2001-07-31
JPH0789898A	1995-04-04
JPH1029979A	1998-02-03

See also references of EP 1426046A4

Aoyama, Tamotsu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)

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