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Title:
NOVEL VACCINIA VIRUS VARIANT WITH INCREASED EXTRACELLULAR ENVELOPED VIRUS PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2023/128672
Kind Code:
A1
Abstract:
The present invention relates to a vaccinia virus with increased extracellular enveloped virus production, and the like. The vaccinia virus of the present invention improves intratumoral virus spread by increasing the production of extracellular enveloped virus related to viral transmission, thereby maximizing the oncolytic potential of vaccinia virus, and thus is expected to exhibit a significantly high anticancer effect compared to conventional vaccinia viruses.

Inventors:
SON WOO-CHAN (KR)
LEE JI-YOUNG (KR)
SON HOSUN (KR)
KIM TAEHEE (KR)
KO SOO MIN (KR)
LEE JANGMI (KR)
KANG JIYEON (KR)
JEONG DA SOM (KR)
LIM HEE SEON (KR)
LEE DONGHYUN (KR)
Application Number:
PCT/KR2022/021646
Publication Date:
July 06, 2023
Filing Date:
December 29, 2022
Export Citation:
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Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C12N7/00; A61K35/76; A61P35/00
Domestic Patent References:
WO2021076982A12021-04-22
Foreign References:
US8329164B22012-12-11
JP2015535687A2015-12-17
KR20140112255A2014-09-23
KR101082296B12011-11-09
Other References:
SHCHELKUNOV S. N., YAKUBITSKIY S. N., BAUER T. V., SERGEEV A. A., KABANOV A. S., BULICHEV L. E., YURGANOVA I. A., ODNOSHEVSKIY D. : "The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice", ACTA NATURAE, PARK MEDIA, RU, vol. 12, no. 4, 22 December 2020 (2020-12-22), RU , pages 120 - 132, XP093075228, ISSN: 2075-8251, DOI: 10.32607/actanaturae.10972
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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