Title:
NOVEL VITAMIN D RECEPTOR MODULATOR WITH PARTIAL AGONIST ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2012/118154
Kind Code:
A1
Abstract:
Provided is a compound that functions as a selective vitamin D receptor modulator and has effect selectivity or tissue selectivity that induces other effects, without inducing hypercalcemia. The compound indicated by formula (I), a solvate of same, or a prodrug thereof. (In the formula, m and n are each independently 1 or 0, R is a hydrogen atom or an alkyl group, Y is an ethane-1, 1-diyl group or an ethyne-1, 2-diyl group, Z1 is a hydrogen atom, Z2 is a hydroxyalkoxy group, or both Z1 and Z2 jointly form a methylene group.)
More Like This:
Inventors:
MAKISHIMA MAKOTO (JP)
YAMADA SACHIKO (JP)
ANTONIO MOURINO (ES)
TOKIWA HIROAKI (JP)
KUDO TAKERU (JP)
WATARAI YUSUKE (JP)
MAEKAWA KAZUKI (JP)
YAMADA SACHIKO (JP)
ANTONIO MOURINO (ES)
TOKIWA HIROAKI (JP)
KUDO TAKERU (JP)
WATARAI YUSUKE (JP)
MAEKAWA KAZUKI (JP)
Application Number:
PCT/JP2012/055254
Publication Date:
September 07, 2012
Filing Date:
March 01, 2012
Export Citation:
Assignee:
UNIV NIHON (JP)
RIKKYO GAKUIN (JP)
MAKISHIMA MAKOTO (JP)
YAMADA SACHIKO (JP)
ANTONIO MOURINO (ES)
TOKIWA HIROAKI (JP)
KUDO TAKERU (JP)
WATARAI YUSUKE (JP)
MAEKAWA KAZUKI (JP)
RIKKYO GAKUIN (JP)
MAKISHIMA MAKOTO (JP)
YAMADA SACHIKO (JP)
ANTONIO MOURINO (ES)
TOKIWA HIROAKI (JP)
KUDO TAKERU (JP)
WATARAI YUSUKE (JP)
MAEKAWA KAZUKI (JP)
International Classes:
C07C401/00; A61K31/59; A61P3/10; A61P9/00; A61P17/06; A61P19/10; A61P25/28; A61P31/00; A61P35/00; A61P37/06; A61P43/00
Foreign References:
| JP2005247768A | 2005-09-15 | |||
| JP2011045022A | 2011-03-03 |
Other References:
NAKABAYASHI, MAKOTO ET AL.: "Crystal Structures of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and Partial Agonism", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 17, 2008, pages 5320 - 5329, XP007914913
See also references of EP 2682386A4
BURY, Y.; STEINMEYER, A.;; CARLBERG, C.: "Structure activity relationship of carboxylic ester antagonists of the vitamin D3 receptor", MOL. PHARMACOL., vol. 58, 2000, pages 1067 - 74
MIURA, D.; MANABE, K.; OZONO, K.; SAITO, M.; GAO, Q.; NORMAN, A.W.; ISHIZUKA, S.: "Antagonistic action of novel lalpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by lalpha,25-dihydroxyvitamin D3", J. BIOL. CHEM., vol. 274, 1999, pages 16392 - 16399
KATO, Y.; NAKANO, Y.; SANO, H.; TANATANI, A.; KOBAYASHI, H.; SHIMAZAWA, R.; KOSHINO, H.; HASHIMOTO, Y.; NAGASAWA, K.: "Synthesis of lalpha,25- dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist", BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 2579 - 2583
BOEHM MF ET AL., CHEM BIOL, vol. 6, 1999, pages 265 - 275
MA Y ET AL., J. CLIN INVES, vol. 116, 2006, pages 892 - 904
HOSODA S ET AL., BIOORG MED CHEM, vol. 14, 2006, pages 5489 - 5502
SATO M ET AL., J BONE MINERAL RES, vol. 25, 2010, pages 1326 - 1336
KASHIWAGI H ET AL., BIOORG MED CHEM, vol. 19, 2011, pages 4721 - 4729
M. IGARASHI ET AL., ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 460, 2007, pages 240 - 253
J. MED. CHEM., vol. 51, 2008, pages 5320 - 5329
MATSUMOTO T; KUBODERA N, JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 103, 2007, pages 584 - 586
MATSUMOTO T ET AL.: "A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 90, 2005, pages 5031 - 5036
SAITO N; HONZAWA S; KITTAKA A, CURR TOP MED CHEM., vol. 6, no. 12, 2006, pages 1273 - 88
ISHIZAWA ET AL., J LIPID RES, vol. 49, 2008, pages 763
IGARASHI ET AL., ARCH BIOCHEM BIOPHYS, vol. 460, 2007, pages 240
See also references of EP 2682386A4
BURY, Y.; STEINMEYER, A.;; CARLBERG, C.: "Structure activity relationship of carboxylic ester antagonists of the vitamin D3 receptor", MOL. PHARMACOL., vol. 58, 2000, pages 1067 - 74
MIURA, D.; MANABE, K.; OZONO, K.; SAITO, M.; GAO, Q.; NORMAN, A.W.; ISHIZUKA, S.: "Antagonistic action of novel lalpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by lalpha,25-dihydroxyvitamin D3", J. BIOL. CHEM., vol. 274, 1999, pages 16392 - 16399
KATO, Y.; NAKANO, Y.; SANO, H.; TANATANI, A.; KOBAYASHI, H.; SHIMAZAWA, R.; KOSHINO, H.; HASHIMOTO, Y.; NAGASAWA, K.: "Synthesis of lalpha,25- dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist", BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 2579 - 2583
BOEHM MF ET AL., CHEM BIOL, vol. 6, 1999, pages 265 - 275
MA Y ET AL., J. CLIN INVES, vol. 116, 2006, pages 892 - 904
HOSODA S ET AL., BIOORG MED CHEM, vol. 14, 2006, pages 5489 - 5502
SATO M ET AL., J BONE MINERAL RES, vol. 25, 2010, pages 1326 - 1336
KASHIWAGI H ET AL., BIOORG MED CHEM, vol. 19, 2011, pages 4721 - 4729
M. IGARASHI ET AL., ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 460, 2007, pages 240 - 253
J. MED. CHEM., vol. 51, 2008, pages 5320 - 5329
MATSUMOTO T; KUBODERA N, JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 103, 2007, pages 584 - 586
MATSUMOTO T ET AL.: "A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 90, 2005, pages 5031 - 5036
SAITO N; HONZAWA S; KITTAKA A, CURR TOP MED CHEM., vol. 6, no. 12, 2006, pages 1273 - 88
ISHIZAWA ET AL., J LIPID RES, vol. 49, 2008, pages 763
IGARASHI ET AL., ARCH BIOCHEM BIOPHYS, vol. 460, 2007, pages 240
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
Setsuko Mayama (JP)
Setsuko Mayama (JP)
Download PDF:
Claims:
Previous Patent: PROTECTIVE ELEMENT
Next Patent: COOLING STRUCTURE FOR OPEN X-RAY SOURCE, AND OPEN X-RAY SOURCE
Next Patent: COOLING STRUCTURE FOR OPEN X-RAY SOURCE, AND OPEN X-RAY SOURCE