Title:
NOVEL VITAMIN E-BASED AMPHIPATHIC COMPOUND, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/088374
Kind Code:
A1
Abstract:
The present invention relates to a vitamin E-based amphipathic compound, a method for producing same, and a method for extracting, solubilizing, stabilizing, or crystalizing a membrane protein using same. By using a compound according to the present invention, not only is an excellent membrane protein extraction and solubilization effect achieved, but the membrane protein can be stably stored for a long period of time in an aqueous solution, and thus the compound can be utilized in analyzing the function and structure of the membrane protein. Moreover, the vitamin E-based amphipathic compounds exhibited superb properties in the visualization of protein compounds through a electron microscope. Membrane protein structure and function analysis is one of the fields of greatest interest in biology and chemistry today, and since at least half of new drugs currently being developed target membrane proteins, the vitamin E-based amphipathic compounds may be applied to the membrane protein structure research, which is closely related to the development of new drugs.
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Inventors:
CHAE PIL SEOK (KR)
MUHAMMAD EHSAN (KR)
MUHAMMAD EHSAN (KR)
Application Number:
PCT/KR2018/002462
Publication Date:
May 09, 2019
Filing Date:
February 28, 2018
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07H15/18; C07K1/14; G01N1/28; G01N33/68
Foreign References:
| KR20170117894A | 2017-10-24 | |||
| US20100311956A1 | 2010-12-09 | |||
| US9695209B2 | 2017-07-04 | |||
| JP2001262192A | 2001-09-26 | |||
| US5102895A | 1992-04-07 |
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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