Title:
NOVEL SMG−1
Document Type and Number:
WIPO Patent Application WO/2002/095025
Kind Code:
A1
Abstract:
A novel polypeptide and a novel polynucleotide encoding the same. This polypeptide, which is an SMG−1 belonging to the phosphatidyl−inositol kinase−associated kinase family, is useful in constructing a system for screening a remedy and&sol or a preventive for pathological conditions caused by the formation of an early transcription termination codon due to a nonsense mutation.
Inventors:
OHNO SHIGEO (JP)
Application Number:
PCT/JP2001/010234
Publication Date:
November 28, 2002
Filing Date:
November 22, 2001
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
OHNO SHIGEO (JP)
OHNO SHIGEO (JP)
International Classes:
A61P21/04; A61P35/00; A61P43/00; C12N1/15; C12N1/21; C12N9/12; C12N15/12; C12N15/54; C12Q1/48; (IPC1-7): C12N15/09; C12N15/12; C12N15/54; C12N1/15; C12N1/21; C12N5/10; C12Q1/48; C12Q1/02; A01K67/027; G01N33/53; A61K31/58; A61K31/552; A61K31/7036; A61P43/00; A61P21/04; A61P35/00
Domestic Patent References:
| WO2001027288A1 | 2001-04-19 |
Other References:
Jann N. SARKARIA et al., "Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent", Caffeine., CANCER RESEARCH, Vol. 59, No.17, P.4375-4382, 01 September 1999 (01.09.99)
Jann N. SARKARIA et al., "Inhibition of Phosphoinsitide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin.," CANCER RESEARCH, Vol.58, No.19, p.4375-4382, 01 October 1998 (01.10.98)
Michelle F. PAGE et al., "SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast.," MOLECULAR AND CELLULAR BIOLOGY, Vol.19, No.9, p.5943-5951, September 1999
Gabriela DENNING et al., "Cloning of a Novel Phosphatidylinositol Kinase-related Kinase.," THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.276, No.25, p. 22709-22714, 22 June 2001 (22.06.01)
Yanashita A et al., "Human SMG-1, a novel Phosphatidylinositol3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.," Genes Dev, Vol.15, No.17, p.2215-2228, 01 September 2001 (01.09.01)
Jann N. SARKARIA et al., "Inhibition of Phosphoinsitide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin.," CANCER RESEARCH, Vol.58, No.19, p.4375-4382, 01 October 1998 (01.10.98)
Michelle F. PAGE et al., "SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast.," MOLECULAR AND CELLULAR BIOLOGY, Vol.19, No.9, p.5943-5951, September 1999
Gabriela DENNING et al., "Cloning of a Novel Phosphatidylinositol Kinase-related Kinase.," THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.276, No.25, p. 22709-22714, 22 June 2001 (22.06.01)
Yanashita A et al., "Human SMG-1, a novel Phosphatidylinositol3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.," Genes Dev, Vol.15, No.17, p.2215-2228, 01 September 2001 (01.09.01)
Attorney, Agent or Firm:
Morita, Kenichi (Itabashi-chuo Bldg. 67-8, Itabashi 2-chom, Itabashi-ku Tokyo, JP)
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