Title:
NPP1 FUSION PROTEINS
Document Type and Number:
WIPO Patent Application WO/2011/113027
Kind Code:
A3
Abstract:
The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.
Inventors:
QUINN ANTHONY (US)
HARVEY ALEX J (US)
XIA ZHINAN (US)
HARVEY ALEX J (US)
XIA ZHINAN (US)
Application Number:
PCT/US2011/028233
Publication Date:
March 01, 2012
Filing Date:
March 11, 2011
Export Citation:
Assignee:
SYNAGEVA BIOPHARMA CORP (US)
QUINN ANTHONY (US)
HARVEY ALEX J (US)
XIA ZHINAN (US)
QUINN ANTHONY (US)
HARVEY ALEX J (US)
XIA ZHINAN (US)
International Classes:
C07K19/00; A61P9/00; C12N15/55; C12N15/62; C12N15/85
Foreign References:
| DE20121960U1 | 2004-01-15 |
Other References:
RIK GIJSBERS ET AL.: "Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1", BIOCHEM. J., vol. 371, 2003, pages 321 - 330, XP055116645, DOI: doi:10.1042/BJ20021943
AARON SCHETTER ET AL.: "Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans", DEVELOPMENTAL BIOLOGY, vol. 289, 2 December 2005 (2005-12-02), pages 360 - 371, XP024943696
RIK GIJSBERS ET AL.: "The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site", FEBS LETTERS, vol. 538, 2003, pages 60 - 64, XP004842825
KRISTEN JOHNSON ET AL.: "Chondrogenesis Mediated by PPi Depletion Promotes Spontaneous Aortic Calcification in NPPI-/- Mice", ARTERIOSCLER THROMB VASC BIOL., vol. 25, April 2005 (2005-04-01), pages 686 - 691, XP055118308, DOI: doi:10.1161/01.ATV.0000154774.71187.f0
CRISTINAA STEFAN ET AL.: "NPP-type ectophosphodiesterases: unity in diversity", TREND IN BIOCHEMICAL SCIENCES, vol. 30, no. 10, October 2005 (2005-10-01), pages 542 - 550, XP027637390
AARON SCHETTER ET AL.: "Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans", DEVELOPMENTAL BIOLOGY, vol. 289, 2 December 2005 (2005-12-02), pages 360 - 371, XP024943696
RIK GIJSBERS ET AL.: "The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site", FEBS LETTERS, vol. 538, 2003, pages 60 - 64, XP004842825
KRISTEN JOHNSON ET AL.: "Chondrogenesis Mediated by PPi Depletion Promotes Spontaneous Aortic Calcification in NPPI-/- Mice", ARTERIOSCLER THROMB VASC BIOL., vol. 25, April 2005 (2005-04-01), pages 686 - 691, XP055118308, DOI: doi:10.1161/01.ATV.0000154774.71187.f0
CRISTINAA STEFAN ET AL.: "NPP-type ectophosphodiesterases: unity in diversity", TREND IN BIOCHEMICAL SCIENCES, vol. 30, no. 10, October 2005 (2005-10-01), pages 542 - 550, XP027637390
Attorney, Agent or Firm:
CHANG, Hak J. (128 Spring Street Suite 52, Lexington Massachusetts, US)
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