Title:
NRF2-ACTIVATING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/145459
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound having Nrf2-activation action. Provided are: compounds represented by general formula (I), or compounds of the lower-polarity group among two groups of diastereomers in which the carbon atom indicated by * in general formula (II) is an asymmetric carbon atom; salts of these; and solvates of these.
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Inventors:
MIYABE TOMOYO (JP)
MACHIDA SHINNOSUKE (JP)
OBA YUKA (JP)
KAKEHI MASAKI (JP)
IMADA TAKASHI (JP)
NAKAJIMA TAKESHI (JP)
MACHIDA SHINNOSUKE (JP)
OBA YUKA (JP)
KAKEHI MASAKI (JP)
IMADA TAKASHI (JP)
NAKAJIMA TAKESHI (JP)
Application Number:
PCT/JP2021/048868
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
International Classes:
C07D419/10; A61K31/554; A61P17/06; A61P25/00; A61P27/02; A61P43/00; C07D515/04
Domestic Patent References:
| WO2021002473A1 | 2021-01-07 | |||
| WO2020041169A2 | 2020-02-27 | |||
| WO2015092713A1 | 2015-06-25 | |||
| WO2016202253A1 | 2016-12-22 |
Foreign References:
| JP2020502123A | 2020-01-23 | |||
| JP2008273924A | 2008-11-13 |
Other References:
TOM D. HEIGHTMAN, JAMES F. CALLAHAN, ELISABETTA CHIARPARIN, JOSEPH E. COYLE, CHARLOTTE GRIFFITHS-JONES, AMI S. LAKDAWALA, RACHEL M: "Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, no. 9, 9 May 2019 (2019-05-09), US , pages 4683 - 4702, XP055768030, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00279
"Japanese Pharmacopoeia", article "General Rules for Preparations, Preparations for Ophthalmic Application"
"Japanese Pharmacopoeia", article "General Rules for Preparations, Preparations for Ophthalmic Application"
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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