Title:
NUCLEAR FACTOR OF ACTIVATED T CELLS RECEPTOR
Document Type and Number:
WIPO Patent Application WO2004027079
Kind Code:
A3
Abstract:
Novel nuclear factor of activated T cells ("NFAT") activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The receptor has a putative signal peptide at the N-terminal (amino acids 1-42), an Ig-domain (amino acids 43-150) in the extracellular region, a predicted transmembrane domain (amino acids 164-186), and an predicted ITAM motif (amino acids 220-235) in the cytoplasmic region. The receptor activates NFAT, IL-13 and TNF alpha promoter reporter activities.
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Inventors:
YAO ZHENGBIN (US)
HU GUANGHUI (CN)
LI KANG (US)
YANG JIANHUA (US)
HU GUANGHUI (CN)
LI KANG (US)
YANG JIANHUA (US)
Application Number:
PCT/US2003/029643
Publication Date:
June 23, 2005
Filing Date:
September 19, 2003
Export Citation:
Assignee:
TANOX INC (US)
YAO ZHENGBIN (US)
HU GUANGHUI (CN)
LI KANG (US)
YANG JIANHUA (US)
YAO ZHENGBIN (US)
HU GUANGHUI (CN)
LI KANG (US)
YANG JIANHUA (US)
International Classes:
C07K14/47; C12Q1/00; A61K38/00; (IPC1-7): C07K14/00; C07K5/00; C12Q1/68; A61K38/00; A61K39/395
Other References:
DATABASE GENBANK [online] 30 July 2002 (2002-07-30), TAKEUCHI ET AL., XP002994653, Database accession no. AY121370
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