Title:
NUCLEIC ACID ANALOG AND ANTI-HEPATITIS B VIRUS AGENT
Document Type and Number:
WIPO Patent Application WO/2020/045628
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a nucleic acid analog, and a pharmaceutical composition, an anti-hepatitis virus agent and a preventive or therapeutic agent for a hepatitis virus-related disease each comprising a nucleic acid analog as an active ingredient. This problem can be solved by a compound represented by formula (1) (wherein: Ra represents a hydrogen atom or an alkyl group and Rb represents an oxo group; or Ra represents a hydrogen atom, a halogen atom or an alkyl group and Rb represents an amino group), a prodrug thereof, a pharmaceutically acceptable salt thereof or a solvate of the same.
Inventors:
HAMADA TOMOHITO (JP)
IKEUCHI HIDEYUKI (JP)
INOO KANAKO (JP)
KISHIKAWA YOSUKE (JP)
IKEDA MASANORI (JP)
TAKEDA MIDORI (JP)
IKEUCHI HIDEYUKI (JP)
INOO KANAKO (JP)
KISHIKAWA YOSUKE (JP)
IKEDA MASANORI (JP)
TAKEDA MIDORI (JP)
Application Number:
PCT/JP2019/034125
Publication Date:
March 05, 2020
Filing Date:
August 30, 2019
Export Citation:
Assignee:
DAIKIN IND LTD (JP)
UNIV KAGOSHIMA (JP)
UNIV KAGOSHIMA (JP)
International Classes:
A61K31/7068; A61P1/16; A61P31/12; A61P31/20; A61P35/00; C07H19/073
Domestic Patent References:
| WO2017155082A1 | 2017-09-14 | |||
| WO2017223421A1 | 2017-12-28 |
Foreign References:
| JPS60252418A | 1985-12-13 | |||
| JP2010533659A | 2010-10-28 | |||
| JP2013510904A | 2013-03-28 | |||
| JP2011503234A | 2011-01-27 | |||
| JP2010174019A | 2010-08-12 |
Other References:
GANGANGARI, KISHORE K. ET AL.: "TMSOTf assisted synthesis of 2'-deoxy-2'-[18F] fluoro-p-D- arabinofuranosylcytosine ([18F]FAC", PLOS ONE, vol. 13, no. 5, 1 May 2018 (2018-05-01), pages 1 - 8, XP055696625, ISSN: 1932-6203
WATANABE, KYOICHI A. ET AL.: "Nucleosides. 110. Synthesis and Antiherpes Virus Activity of Some 2'-Fluoro-2'-deoxyarabinofuranosylpyrimidine Nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 1, 1978, pages 21 - 24, XP055696626, ISSN: 0022-2623
CHANG, WON-SUK ET AL.: "Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 15, 8 June 2010 (2010-06-08), pages 4539 - 4543, XP029121119, ISSN: 0960-894X
IKEDA, MASANORI ET AL.: "A new viewpoint of therapeutic agents for hepatitis", MEDICAL SCIENCE DIGEST, vol. 45, no. 1, 25 January 2019 (2019-01-25), pages 38 - 39, ISSN: 1347-4340
WATANABE, KYOICHI A. ET AL.: "Nucleosides. 110. Synthesis and Antiherpes Virus Activity of Some 2'-Fluoro-2'-deoxyarabinofuranosylpyrimidine Nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 1, 1978, pages 21 - 24, XP055696626, ISSN: 0022-2623
CHANG, WON-SUK ET AL.: "Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 15, 8 June 2010 (2010-06-08), pages 4539 - 4543, XP029121119, ISSN: 0960-894X
IKEDA, MASANORI ET AL.: "A new viewpoint of therapeutic agents for hepatitis", MEDICAL SCIENCE DIGEST, vol. 45, no. 1, 25 January 2019 (2019-01-25), pages 38 - 39, ISSN: 1347-4340
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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