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Title:
NUCLEIC ACID COMPLEX
Document Type and Number:
WIPO Patent Application WO/2017/131236
Kind Code:
A1
Abstract:
The present invention relates to the nucleic acid complex expressed by formula 1. Formula 1: (In formula 1, X is an oligonucleotide, L1 and L2 each independently represents a sugar ligand, and S1, S2 and S3 each independently represents a linker.)

Inventors:
UEHARA, Keiji (Kyowa Hakko Kirin Co. Ltd., 1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
SUZUKI, Yasuhiro (Kyowa Hakko Kirin Co. Ltd., 1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
IWAI, Hiroto (Kyowa Hakko Kirin Co. Ltd., 1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
HOMMA, Masakazu (Kyowa Hakko Kirin Co. Ltd., 1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
FUKUDA, Yuichi (Kyowa Hakko Kirin Co. Ltd., 1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
KIUCHI, Tatsuto (Kyowa Hakko Kirin Co. Ltd., 1-6-1, Otemachi, Chiyoda-k, Tokyo 85, 〒1008185, JP)
Application Number:
JP2017/003249
Publication Date:
August 03, 2017
Filing Date:
January 30, 2017
Export Citation:
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Assignee:
KYOWA HAKKO KIRIN CO., LTD. (1-6-1, Otemachi Chiyoda-k, Tokyo 85, 〒1008185, JP)
International Classes:
C12N15/113; A61K31/7088; A61K31/713; A61P43/00; C07C237/10; C07C247/04; C07C271/16; C07H15/04
Domestic Patent References:
WO2014179629A22014-11-06
WO2014179627A22014-11-06
WO2009073809A22009-06-11
WO2013075035A12013-05-23
WO2015105083A12015-07-16
WO2014179620A12014-11-06
WO2005113571A22005-12-01
WO2013173601A12013-11-21
WO2013173637A12013-11-21
WO2015006740A22015-01-15
Foreign References:
JP2014504295A2014-02-20
JP2013521328A2013-06-10
US5804683A1998-09-08
US5831071A1998-11-03
US5998203A1999-12-07
US6117657A2000-09-12
US6353098B12002-03-05
US6362323B12002-03-26
US6437117B12002-08-20
US6469158B12002-10-22
US6111086A2000-08-29
US6008400A1999-12-28
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NAIR JAYAPRAKASH K. ET AL.: "Multivalent N- Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 16958 - 16961, XP055181463
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Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (TMI ASSOCIATES, 23rd Floor Roppongi Hills Mori Tower, 6-10-1, Roppongi, Minato-k, Tokyo 23, 〒1066123, JP)
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