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Title:
NUCLEIC ACID COMPLEX
Document Type and Number:
WIPO Patent Application WO/2019/177061
Kind Code:
A1
Abstract:
According to the present invention, there are developed and provided a nucleic acid agent that is delivered efficiently to the central nervous system where drug delivery is impeded by the blood-brain barrier mechanism and that provides an antisense effect on a target transcript at the delivery location, and a composition that contains the nucleic acid agent. Provided is a double-stranded nucleic acid complex obtained by annealing a first nucleic acid strand that hybridizes with a portion of a target transcript and has an antisense effect on the target transcript and a second nucleic acid strand that includes a base sequence complementary to the first nucleic acid strand and binds with phosphatidylethanolamine or an analog thereof.

Inventors:
YOKOTA Takanori (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
NAGATA Tetsuya (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
FURUKAWA Hideki (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
NAKAGAWA Yasuo (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
YOGO Takatoshi (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
TOKUNOH Ryosuke (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
SASAKI Shigekazu (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
HIDAKA Kosuke (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
SEKI Tomohiro (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
MIYATA Kenichi (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
UCHIDA Akio (26-1 Muraoka-Higashi 2-chome, Fujisawa-sh, Kanagawa 12, 〒2510012, JP)
Application Number:
JP2019/010392
Publication Date:
September 19, 2019
Filing Date:
March 13, 2019
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (5-45, Yushima 1-chome Bunkyo-k, Tokyo 10, 〒1138510, JP)
TAKEDA PHARMACEUTICAL COMPANY LIMITED (1-1 Doshomachi 4-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
International Classes:
C12N15/113; A61K31/711; A61K31/713; A61K47/54; A61K48/00; A61P25/00
Domestic Patent References:
WO2009123185A12009-10-08
WO2011008857A12011-01-20
Foreign References:
JP2016524588A2016-08-18
JP2016526529A2016-09-05
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (Atago Green Hills MORI Tower 32F, 5-1 Atago 2-chome, Minato-k, Tokyo 32, 〒1056232, JP)
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