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Patent Searching and Data


Title:
NUCLEIC ACID COMPLEX
Document Type and Number:
WIPO Patent Application WO/2019/177061
Kind Code:
A1
Abstract:
According to the present invention, there are developed and provided a nucleic acid agent that is delivered efficiently to the central nervous system where drug delivery is impeded by the blood-brain barrier mechanism and that provides an antisense effect on a target transcript at the delivery location, and a composition that contains the nucleic acid agent. Provided is a double-stranded nucleic acid complex obtained by annealing a first nucleic acid strand that hybridizes with a portion of a target transcript and has an antisense effect on the target transcript and a second nucleic acid strand that includes a base sequence complementary to the first nucleic acid strand and binds with phosphatidylethanolamine or an analog thereof.

Inventors:
YOKOTA TAKANORI (JP)
NAGATA TETSUYA (JP)
FURUKAWA HIDEKI (JP)
NAKAGAWA YASUO (JP)
YOGO TAKATOSHI (JP)
TOKUNOH RYOSUKE (JP)
SASAKI SHIGEKAZU (JP)
HIDAKA KOSUKE (JP)
SEKI TOMOHIRO (JP)
MIYATA KENICHI (JP)
UCHIDA AKIO (JP)
Application Number:
JP2019/010392
Publication Date:
September 19, 2019
Filing Date:
March 13, 2019
Export Citation:
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Assignee:
NATIONAL UNIV CORPORATION TOKYO MEDICAL AND DENTAL UNIV (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C12N15/113; A61K31/711; A61K31/713; A61K47/54; A61K48/00; A61P25/00
Domestic Patent References:
WO2009123185A12009-10-08
WO2011008857A12011-01-20
WO2017053999A12017-03-30
WO2007143315A22007-12-13
WO2008043753A22008-04-17
WO2008049085A12008-04-24
Foreign References:
JP2016524588A2016-08-18
JP2016526529A2016-09-05
JP2018047294A2018-03-29
Other References:
"GenBank", Database accession no. NR_002847
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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