Title:
NUCLEIC ACID COMPOUND AND OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2018/155451
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a nucleic acid compound represented by formula (I) or formula (II), said nucleic acid compound hardly forming a non-Watson-Crick base pair; and an oligonucleotide which comprises the nucleic acid compound and in which non-specific binding to a nucleic acid other than a target nucleic acid is diminished. The nucleic acid compound according to the present invention is characterized in that the carbonyl group at the 2-position of pyrimidine base is converted into a functional group (wherein X1 and X2 independently represent S or Se), and the 2'- and 4'-positions are crosslinked by a specific structure. The oligonucleotide according to the present invention is characterized in that thymidine and/or uridine therein are the aforesaid nucleic acid compound(s).
Inventors:
OBIKA SATOSHI (JP)
ITO KOSUKE (JP)
HABUCHI TAKAAKI (JP)
HORIBA MASAHIKO (JP)
ITO KOSUKE (JP)
HABUCHI TAKAAKI (JP)
HORIBA MASAHIKO (JP)
Application Number:
PCT/JP2018/006062
Publication Date:
August 30, 2018
Filing Date:
February 20, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C07H19/10; C07H21/02; C12N15/11; C12N15/113; A61K31/7125; A61P43/00; C12N15/09
Domestic Patent References:
| WO2014046212A1 | 2014-03-27 | |||
| WO2015125783A1 | 2015-08-27 | |||
| WO2011052436A1 | 2011-05-05 | |||
| WO2011052436A1 | 2011-05-05 | |||
| WO2014046212A1 | 2014-03-27 | |||
| WO2014112463A1 | 2014-07-24 | |||
| WO2015125783A1 | 2015-08-27 | |||
| WO2016017422A1 | 2016-02-04 |
Foreign References:
| US20040033973A1 | 2004-02-19 | |||
| JP2017030490A | 2017-02-09 |
Other References:
HABUCHI, TAKAKI ET AL.: "27U-am09S Synthesis and property of scpBNA-2-thiothymine", 137TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 137, 1 February 2017 (2017-02-01), pages 134, XP009516364, ISSN: 0918-9823
SINTIM, H. O. ET AL.: "Enhanced base pairing and replication efficiency of thiothymidines , expanded-size variants of thymidine", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 396 - 397, XP055555149
OBIKA, S ET AL., NUCLEIC ACIDS RES., vol. 37, 2009, pages 1225 - 1238
HERMAN. 0 ET AL., J. AM. CHEM. SOC., vol. 128, 2006, pages 396 - 397
SEKINE, M ET AL., J. ORG. CHEM., vol. 68, 2003, pages 9971 - 9982
HUANG, Z ET AL., J. AM. CHEM. SOC., vol. 132, 2020, pages 2120 - 2121
NUCLEIC ACID THER., vol. 22, no. 5, 2012, pages 344 - 359
See also references of EP 3587432A4
SINTIM, H. O. ET AL.: "Enhanced base pairing and replication efficiency of thiothymidines , expanded-size variants of thymidine", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 396 - 397, XP055555149
OBIKA, S ET AL., NUCLEIC ACIDS RES., vol. 37, 2009, pages 1225 - 1238
HERMAN. 0 ET AL., J. AM. CHEM. SOC., vol. 128, 2006, pages 396 - 397
SEKINE, M ET AL., J. ORG. CHEM., vol. 68, 2003, pages 9971 - 9982
HUANG, Z ET AL., J. AM. CHEM. SOC., vol. 132, 2020, pages 2120 - 2121
NUCLEIC ACID THER., vol. 22, no. 5, 2012, pages 344 - 359
See also references of EP 3587432A4
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
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