Title:
NUCLEIC ACID DETECTION METHOD, COMPOUND AND FLUORESCENT PROBE
Document Type and Number:
WIPO Patent Application WO/2022/124148
Kind Code:
A1
Abstract:
Provided is a compound which is suited to nucleic acid detection or viscosity measurement. The disclosed compound is equipped with a donor and three acceptors which are bonded to said donor so as to be capable of rotating around said donor, and exhibits a change in fluorescence properties according to a change in the rotation of each acceptor.
Inventors:
SAKAMOTO TAKASHI (JP)
Application Number:
PCT/JP2021/043996
Publication Date:
June 16, 2022
Filing Date:
November 30, 2021
Export Citation:
Assignee:
UNIV WAKAYAMA (JP)
International Classes:
C07D277/64; C12N15/11; C12Q1/68; G01N21/64; G01N21/78
Domestic Patent References:
| WO2017033162A1 | 2017-03-02 | |||
| WO2017033163A1 | 2017-03-02 |
Foreign References:
| JP2020176108A | 2020-10-29 | |||
| JP2020206368A | ||||
| US10683273B2 | 2020-06-16 |
Other References:
NAGARJUN NARAYANASWAMY, SHUBHAJIT DAS, PRALOK K. SAMANTA, KHADIJA BANU, GURU PRASAD SHARMA, NEELIMA MONDAL, SUMAN K. DHAR, SWAPAN : "Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 43, no. 18, 15 October 2015 (2015-10-15), GB , pages 8651 - 8663, XP055328442, ISSN: 0305-1048, DOI: 10.1093/nar/gkv875
SAKAMOTO, TAKASHI; YU, ZEHUI; OTANI, YUTO: "A23-1am-03 Simultaneous detection of double-stranded and G4 DNA with tripodal quinone-cyanine dye", PROCEEDINGS OF SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ), vol. 101, 19 March 2021 (2021-03-19) - 22 March 2021 (2021-03-22), JP, XP009537400
NAGARJUN NARAYANASWAMY ET AL.: "Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications", NUCLEIC ACIDS RESEARCH, vol. 43, no. 18, 2015, pages 8651 - 8663, XP055328442, DOI: 10.1093/nar/gkv875
NAAMA KARTON-LIFSHIN ET AL.: "Donor-Two-Acceptor'' Dye Design: A Distinct Gateway to NIR Fluorescence", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, pages 20412 - 20420, XP055306936, DOI: 10.1021/ja308124q
SAKAMOTO, TAKASHI; YU, ZEHUI; OTANI, YUTO: "A23-1am-03 Simultaneous detection of double-stranded and G4 DNA with tripodal quinone-cyanine dye", PROCEEDINGS OF SPRING MEETING OF THE CHEMICAL SOCIETY OF JAPAN (CSJ), vol. 101, 19 March 2021 (2021-03-19) - 22 March 2021 (2021-03-22), JP, XP009537400
NAGARJUN NARAYANASWAMY ET AL.: "Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications", NUCLEIC ACIDS RESEARCH, vol. 43, no. 18, 2015, pages 8651 - 8663, XP055328442, DOI: 10.1093/nar/gkv875
NAAMA KARTON-LIFSHIN ET AL.: "Donor-Two-Acceptor'' Dye Design: A Distinct Gateway to NIR Fluorescence", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, pages 20412 - 20420, XP055306936, DOI: 10.1021/ja308124q
Attorney, Agent or Firm:
SAKAMOTO Hiroshi (JP)
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