Title:
NUCLEIC ACID DRUG SUPPRESSING PRODUCTION OF MYOSTATIN GENE MRNA
Document Type and Number:
WIPO Patent Application WO/2020/262184
Kind Code:
A1
Abstract:
Provided is a novel method for inhibiting myostatin. An antisense oligonucleotide having a base length of 15-30 that has a base sequence complementary to the target site of exon 1 of myostatin gene, a salt thereof or a solvate of the same, said antisense oligonucleotide being capable of suppressing the production of mRNA of myostatin gene. A medicine, a food, a feed, a drug for promoting the growth and/or enlargement of muscle cells, a drug for increasing muscle amount and/or inhibiting muscular depression, a drug for suppressing the production of mRNA of myostatin gene, and a myostatin function inhibitor, each comprising the aforesaid antisense oligonucleotide, a salt thereof or a solvate of the same.
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Inventors:
MATSUO MASAFUMI (JP)
MAETA KAZUHIRO (JP)
MAETA KAZUHIRO (JP)
Application Number:
PCT/JP2020/023917
Publication Date:
December 30, 2020
Filing Date:
June 18, 2020
Export Citation:
Assignee:
KNC LABORATORIES CO LTD (JP)
KOBE GAKUIN EDUCATIONAL FOUND (JP)
KOBE GAKUIN EDUCATIONAL FOUND (JP)
International Classes:
A61K48/00; A23K20/153; A23L33/13; A61K31/7088; A61K31/712; A61K31/7125; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P13/12; A61P19/02; A61P19/08; A61P21/02; A61P21/04; A61P29/00; A61P43/00; C12N15/113
Domestic Patent References:
| WO1999014226A2 | 1999-03-25 | |||
| WO1998054198A1 | 1998-12-03 |
Foreign References:
| JP2017500373A | 2017-01-05 | |||
| US20050124566A1 | 2005-06-09 | |||
| JP2003517580A | 2003-05-27 | |||
| CN106086031A | 2016-11-09 | |||
| JP2019118446A | 2019-07-22 | |||
| US6261840B1 | 2001-07-17 | |||
| JPH0787982A | 1995-04-04 | |||
| JP2000297097A | 2000-10-24 |
Other References:
ST ANDRE ET AL., SKELETAL MUSCLE, vol. 7, 2017, pages 25
KANG ET AL., MOL THER, vol. 19, 2011, pages 159 - 64
BLOMMERS ET AL., BIOCHEMISTRY, vol. 37, 1998, pages 17714 - 17725
LESNIK, E.A. ET AL., BIOCHEMISTRY, vol. 32, 1993, pages 7832 - 7838
MARTIN, P., HELV. CHIM. ACTA., vol. 78, 1995, pages 486 - 504
TETRAHEDRON LETTERS, vol. 32, 1991, pages 3005
J. AM. CHEM. SOC., vol. 112, 1990, pages 1253
"Oligonucleotide Synthesis", 1984, OXFORD UNIVERSITY PRESS
"Gene Bank", Database accession no. NG_009800.1
WADA ET AL., DEVELOPMENT, vol. 129, 2002, pages 2987 - 2995
See also references of EP 3995153A4
KANG ET AL., MOL THER, vol. 19, 2011, pages 159 - 64
BLOMMERS ET AL., BIOCHEMISTRY, vol. 37, 1998, pages 17714 - 17725
LESNIK, E.A. ET AL., BIOCHEMISTRY, vol. 32, 1993, pages 7832 - 7838
MARTIN, P., HELV. CHIM. ACTA., vol. 78, 1995, pages 486 - 504
TETRAHEDRON LETTERS, vol. 32, 1991, pages 3005
J. AM. CHEM. SOC., vol. 112, 1990, pages 1253
"Oligonucleotide Synthesis", 1984, OXFORD UNIVERSITY PRESS
"Gene Bank", Database accession no. NG_009800.1
WADA ET AL., DEVELOPMENT, vol. 129, 2002, pages 2987 - 2995
See also references of EP 3995153A4
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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