INTERNATIONAL SEARCH REPORT Inter, nal Application No PCT/US 00/15873 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. X HU GANG ET AL :"Siah-1 N-terminal RING 1-4, domain is required for proteolysis 6-14,16, function, and C-terminal sequences 18-28, regulate oligomerization and binding to 30,31,33 target proteins." MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 1, January 1999 (1999-01), pages 724-732, XP002153980 ISSN: 0270-7306 the whole document X MATSUZAWA SHU-ICHI ET AL :"p53-inducible 1-4, human homologue of Drosophila seven in 6-14,16, absentia (Siah) inhibits cell growth: 18-28, Suppression by BAG-1."30, 31,33 EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 10,15 May 1998 (1998-05-15), pages 2736-2747, XP002153981 ISSN: 0261-4189 cited in the application the whole document A KINZLER KENNETH W ET AL:"Lessons from 32 hereditary colorectal cancer." CELL, vol. 87, no. 2,1996, pages 159-170, XP002153982 ISSN: 0092-8674 cited in the application the whole document X WO 98 42741 A (GENETICS INST) 1-35 1 October 1998 (1998-10-01) the whole document especially SEQ ID NO 1 and 2 X EMBL DATABASE Accession no AL035305,1-28 Sequence ID HS102G201 28 January 1999 RHODES S:"H. sapiens gene from PAC 102G20" XP002160981 the whole document -& EMBL DATABASE Accession no 060666, Sequence ID 0060666 01 August 1998 TU C ET AL:"Hypothetical 26.2 KDA protein" XP002160982 4 4 INTERNATIONAL SEARCH REPORT PCT/US 00/15873 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category ° Citation of document, with indication, where appropnate, of the relevant passages Relevant to claim No. X FILIPEK ANNA ET AL:"Molecular cloning 1-28 and expression of a mouse brain cDNA encoding a novel protein target of calcylin." JOURNAL OF NEUROCHEMISTRY, vol. 70, no. 5, May 1998 (1998-05), pages 1793-1798,XP000982427 ISSN: 0022-3042 the whole document P, X WO 99 46374 A (SCHMITT ARMIN; SPECHT 1-35 THOMAS (DE); DAHL EDGAR (DE); HINZMANN BERND) 16 September 1999 (1999-09-16) the whole document especially SEQ ID No 142 and 143 X WO 98 41624 A (WALLACH DAVID ; YEDA RES & 1-4, DEV (IL) ; KOVALENKO ANDREI (IL)) 6-14,16, 24 September 1998 (1998-09-24) 18-35 the whole document P, X CENCIARELLI C ET AL:"Identification of a 1-28 family of human F-box proteins." CURRENT BIOLOGY, vol. 9, no. 20, 21 October 1999 (1999-10-21), pages 1177-1179,XP000982510 ISSN: 0960-9822 the whole document P, X-& EMBL DATABASE Accession no Q9UKT2 1-4, Sequence ID Q9UKT2 6-14,16, 1 May 2000 18-28 XP002160984 X-& EMBL DATABASE Accession no 075986 1-28 Sequence ID 075986 1 November 1998 XP002160985 P, X-& EMBL DATABASE Accession no Q9UKT4 1-28 Sequence ID Q9UKT4 1 May 2000 XP002160991 P, X EMBL DATABASE Accession no Q9Y3I1 Sequence 1-28 IDQ9Y3I1 1 November 1999 ILYIN GENNADY P ET AL :"cDNA cloning and expression analysis of new members of the mammalian F-box protein family" XP002160986 the whole document P, X WO 99 47540 A (ENDRESS GREGORY A; HUMAN 1-4, GENOME SCIENCES INC (US); FENG PING (US);) 6-14,16, 23 September 1999 (1999-09-23) 18-28 SEQ ID NO 197 4 _/__ INTERNATIONAL SEARCH REPORT Inte ional Application No PCT/US 00/15873 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. P, X EMBL DATABASE Accession no Q9Y593 Sequence 1-4, UD Q9Y593 6-14,16, 1 November 1999 18-28 SCANLAN M ET AL:"Antigens recognized by autologous antibody in patients with renal carcinoma" XP002160987 the whole document P, X EMBL DATABASE Accession no Q9UK97 Sequence 1-4, ID Q9UK97 6-14,16, 1 May 2000 18-28 WINSTON J ET AL:"A familiy of mammalian F-box proteins" XP002160988 the whole document X WO 99 18989 A (BAYLOR COLLEGE MEDICINE) 1-4, 22 April 1999 (1999-04-22) 6-14,16, 18-28 F16 (SEQ ID NO 41 and 43) 4 international application No. INTERNATIONAL SEARCH REPORT PCT/US 00/15873 Box I Observations where certain claims were found unsearchable (Continuation of item 1 of first sheet) This International Search Report has not been established in respect of certain claims under Article 17 (2) (a) for the following reasons: 1.3 Claims Nos.: because they relate to subject matter not required to be searched by this Authority, namely: Although claims 29 31-33 35 36 and 43 are (partially) directed to a method of treatment of the human/animal body, the search has been carried out and based on the alleged effects of the compound/composition. 2. E Claims Nos.: 40 because they relate to parts of the International Application that do not comply with the prescribed requirements to such an extent that no meaningful International Search can be carried out, specifically: see FURTHER INFORMATION sheet PCT/ISA/210 3. Claims Nos.: because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4 (a). Box 11 Observations where unity of invention is lacking (Continuation of item 2 of first sheet) This International Searching Authority found multiple inventions in this international application, as follows: see additional sheet 1. 1. As all required additional search fees were timely paid by the applicant, this International Search Report covers all searchable claims. 2. As aii searchable claims could be searched without effort justifying an additional fee, this Authority did not invite payment of any additional fee. 3. As only some of the required additional search fees were timely paid by the applicant, this International Search Report covers only those claims for which fees were paid, specifically claims Nos.: 4. No required additional search fees were timely paid by the applicant. Consequently, this International Search Report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: Remark on Protest The additional search fees were accompanied by the applicant's protest. Fx-l No protest accompanied the payment of additional search fees. u FURTHER INFORMATION CONTINUED FROM PCT/ISAJ 210 This International Searching Authority found multiple (groups of) inventions in this international application, as follows: 1. Claims: 1-39 41-44 partially Siah-1-alpha (SEQ ID NO 2), its encoding nucleotides, antibodies against the protein and their use 2. Claims: 1-39 41-44 partially SIP proteins (SEQ ID NO 4 and 6), their encoding nucleotides, antibodies against the proteins and their use 3. Claims: 1-39 41-44 partially SAF-1 proteins (SEQ ID NO 8 and 10), their encoding nucleotides, antibodies against the proteins and their use 4. Claims: 1-39 41-44 partially SAF-2 protein (SEQ ID NO 12), its encoding nucleotides, antibodies against the protein and their use 5. Claims: 1-39 41-44 partially SAD protein, its encoding nucleotides, antibodies against the protein and their use FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 Continuation of Box 1. 2 Claims Nos.: 40 Present claim 40 relate to a chimeric nucleic acid defined by reference to a desirable characteristic or property, namely encoding a chimera of a protein degradation binding domain and a polypeptide being able to modulate a cellular phenotype. The claim covers all products having this characteristic or property, whereas the application provides no support within the meaning of Article 6 PCT and/or disclosure within the meaning of Article 5 PCT for any such product. In the present case, the claims so lack support, and the application so lacks disclosure, that a meaningful search over the whole of the claimed scope is impossible. Independent of the above reasoning, the claims also lack clarity (Article 6 PCT). An attempt is made to define the product by reference to a result to be achieved. Again, this lack of clarity in the present case is such as to render a meaningful search over the whole of the claimed scope impossible. Consequently, no search has been carried out. The applicant's attention is drawn to the fact that claims, or parts of claims, relating to inventions in respect of which no international search report has been established need not be the subject of an international preliminary examination (Rule 66.1 (e) PCT). The applicant is advised that the EPO policy when acting as an International Preliminary Examining Authority is normally not to carry out a preliminary examination on matter which has not been searched. This is the case irrespective of whether or not the claims are amended following receipt of the search report or during any Chapter II procedure. INTERNATIONAL SEARCH REPORT Intei Wal Application No Information on patent family members PCT/US 00/15873 Patent document Publication Patent family Publication cited in search report date member (s) date WO 9722695 A 26-06-1997 FR 2742766 A 27-06-1997 FR 2747691 A 24-10-1997 CA 2240449 A 26-06-1997 EP 0868512 A 07-10-1998 JP 2000502893 T 14-03-2000 WO 9842741 A 01-10-1998 AU 6777298 A 20-10-1998 EP 0998490 A 10-05-2000 WO 9946374 A 16-09-1999 DE 19811193 A 16-09-1999 EP 1068317 A 17-01-2001 WO 9841624 A 24-09-1998 AU 6634798 A 12-10-1998 BR 9808915 A 01-08-2000 CN 1250479 T 12-04-2000 EP 0972033 A 19-01-2000 NO 994524 A 11-11-1999 WO 9947540 A 23-09-1999 AU 3451799 A 11-10-1999 EP 1064297 A 03-01-2001 AU 3072799 A 11-10-1999 WO 9947538 A 23-09-1999 WO 9918989 A 22-04-1999 AU 1088399 A 03-05-1999