Title:
NUCLEIC ACID HOMOLOGUE
Document Type and Number:
WIPO Patent Application WO/1993/024512
Kind Code:
A1
Abstract:
An object of the invention is to provide a novel antisense molecule utilizable as a medicine which suppresses infection with herpesvirus, influenza virus, human immunodeficiency virus or the like and the action of cancer genes. The nucleic acid homologue of the invention is one represented by general formula (I), wherein X and Y may be the same or different from each other and each represents S or O; B?1¿, B?2¿, B?3¿ and B?4¿ may be the same or different from one another and each represents adenine, guanine, hypoxanthine, cytosine, thymine or uracil; and n represents an integer of 1 or above, provided that B?2¿ and B?3¿ need not necessarily be one and the same base when n is 2 or above.
Inventors:
YANO JUNICHI (JP)
OHGI TADAAKI (JP)
ISHIYAMA KOUICHI (JP)
OHGI TADAAKI (JP)
ISHIYAMA KOUICHI (JP)
Application Number:
PCT/JP1993/000684
Publication Date:
December 09, 1993
Filing Date:
May 24, 1993
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
YANO JUNICHI (JP)
OHGI TADAAKI (JP)
ISHIYAMA KOUICHI (JP)
YANO JUNICHI (JP)
OHGI TADAAKI (JP)
ISHIYAMA KOUICHI (JP)
International Classes:
C07H21/00; (IPC1-7): C07H21/04
Other References:
ORGANIC SYNTHETIC CHEMISTRY, Vol. 48, No. 3, pages 180 to 193, March 1990, MURAKAMI, MAKINO, "Chemical Synthesis of Functional Anti-Sense DNA".
JOURNAL OF ORGANIC CHEMISTRY, Vol. 42, No. 4, p. 703-706, (1977), W.S. MUNGALL et al., "Carbamate Analogues of Oligonucleotides".
NUCLEOSIDE & NUCLEOTIDES, Vol. 9, No. 2, p. 259-273, (1990), M.J. DE VOS et al., "Solid Phase Nonisotopic Labeling of Oligodeoxy Nucleotides Using 5'-Protected Aminoalkyl Phosphoramidates".
JOURNAL OF ORGANIC CHEMISTRY, Vol. 42, No. 4, p. 703-706, (1977), W.S. MUNGALL et al., "Carbamate Analogues of Oligonucleotides".
NUCLEOSIDE & NUCLEOTIDES, Vol. 9, No. 2, p. 259-273, (1990), M.J. DE VOS et al., "Solid Phase Nonisotopic Labeling of Oligodeoxy Nucleotides Using 5'-Protected Aminoalkyl Phosphoramidates".
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